Human threat circuitsBertram, Teresa (Avtor) Hoffmann Ayala, Daniel (Avtor) Huber, Eva Maria (Avtor) Brandl, Felix (Avtor) Starke, Georg (Avtor) Sorg, Christian (Avtor) Mulej Bratec, Satja (Avtor) humanthreat responsestranslational neurosciencethreat conditioningthreat typesMRIthreat circuitThreat processing, enabled by threat circuits, is supported by a remarkably conserved neural architecture across mammals. Threatening stimuli relevant for most species include the threat of being attacked by a predator or an aggressive conspecific and the threat of pain. Extensive studies in rodents have associated the threats of pain, predator attack and aggressive conspecific attack with distinct neural circuits in subregions of the amygdala, the hypothalamus and the periaqueductal gray. Bearing in mind the considerable conservation of both the anatomy of these regions and defensive behaviors across mammalian species, we hypothesized that distinct brain activity corresponding to the threats of pain, predator attack and aggressive conspecific attack would also exist in human subcortical brain regions.Frontiers Research Foundation20232024-04-12 15:14:46Članek v reviji88276sl