Inhibitory synaptic timescales drive oscillatory regime transitions in recurrent excitatory-inhibitory networksKheiri, Siamak (Avtor) Taghavi, Saeed (Avtor) Perc, Matjaž (Avtor) Valizadeh, Alireza (Avtor) biological neural networksinhibitory synapsesneuronal dynamicsspiking neuronssynchronizationIn recurrent cortical networks, inhibitory kinetics are often assumed to tune oscillation frequency continuously. Using a recurrent excitatory-inhibitory (E-I) model with fixed excitatory synaptic dynamics, we systematically vary inhibitory decay time constants and show instead that inhibitory timescale acts as a control parameter that drives sharp transitions between distinct collective states. The network switches between a coherent high-frequency regime and a coherent gamma-band regime, separated by an intermediate transition state with reduced synchrony and unstable phase coordination. Phase analysis demonstrates that the coherent regimes exhibit distinct, internally consistent E-I coordination patterns, whereas these relationships break down in the transition regime. Dissecting inhibitory pathways reveals that inhibitory-to-inhibitory decay times determine the operative regime, while inhibitory-to-excitatory kinetics primarily adjust oscillation frequency and the width of the transition region without altering the global phase structure. Our results link physiological diversity in inhibitory synaptic timescales to discrete oscillatory regimes in recurrent cortical circuits.American Phyisical Society20262026-06-09 14:43:24Znanstveno delo98390sl