Lipoprotein(a) as a risk factor in a cohort of hospitalised cardiovascular patientsŠuran, David (Avtor) Završnik, Tadej (Avtor) Kokol, Peter (Avtor) Kokol, Marko (Avtor) Sinkovič, Andreja (Avtor) Naji, Franjo (Avtor) Završnik, Jernej (Avtor) Blažun Vošner, Helena (Avtor) Kanič, Vojko (Avtor) acute myocardial infarctionaortic valve stenosisatherosclerosiscardiovascular diseasescardiovascular riskischemic heart diseaselipoprotein(a)postmenopausal womenLipoprotein(a) (Lp(a)) is a well-recognised risk factor for ischemic heart disease (IHD) and calcific aortic valve stenosis (AVS). Methods: A retrospective observational study of Lp(a) levels (mg/dL) in patients hospitalised for cardiovascular diseases (CVD) in our clinical routine was performed. The Lp(a)-associated risk of hospitalisation for IHD, AVS, and concomitant IHD/AVS versus other non-ischemic CVDs (oCVD group) was assessed by means of logistic regression. Results: In total of 11,767 adult patients, the association with Lp(a) was strongest in the IHD/AVS group (eβ = 1.010, p < 0.001), followed by the IHD (eβ = 1.008, p < 0.001) and AVS group (eβ = 1.004, p < 0.001). With increasing Lp(a) levels, the risk of IHD hospitalisation was higher compared with oCVD in women across all ages and in men aged ≤75 years. The risk of AVS hospitalisation was higher only in women aged ≤75 years (eβ = 1.010 in age < 60 years, eβ = 1.005 in age 60–75 years, p < 0.05). Conclusions: The Lp(a)-associated risk was highest for concomitant IHD/AVS hospitalisations. The differential impact of sex and age was most pronounced in the AVS group with an increased risk only in women aged ≤75 years.MDPI20232024-06-12 10:06:53Članek v reviji89079UDK: 616.1COBISS_ID: 151715843DOI: 10.3390/jcm12093220ISSN pri članku: 2077-0383sl© 2023 by the authors