Surface analysis of sodium metamizolate as an active pharmaceutical ingredient in solid formFinšgar, Matjaž (Avtor) Varda, Katja Andrina (Avtor) matamizolesodium metamizolateToF-SIMSXPSsurface analysisAPIThis study focuses on the surface and subsurface characterization of a pharmaceutical tablet containing sodium metamizolate (NaMET), with an emphasis on mass spectrometry using time-of-flight secondary ion mass spectrometry (ToF-SIMS). ToF-SIMS enabled the identification of NaMET-specific fragment ions, which served as signals for the determination of the spatial distribution of this active pharmaceutical ingredient (API) within the tablet matrix. A ToF-SIMS fragmentation mechanism for NaMET was proposed based on the ToF-SIMS spectra analysis measured on a NaMET reference standard. 3D ToF-SIMS imaging showed heterogeneous localization of the API across a 5 μm depth. Complementary techniques, including 3D profilometry and atomic force microscopy (AFM), provided surface roughness and morphological data, while X-ray photoelectron spectroscopy (XPS) confirmed the elemental composition and chemical states. Depth profiling by XPS further supported the non-uniform distribution of NaMET.Elsevier B. V.20262025-11-10 08:59:30Članek v reviji95915UDK: 661.12:615COBISS_ID: 256060931DOI: 10.1016/j.ijms.2025.117548ISSN pri članku: 1873-2798sl© 2025 The Authors