20.500.12556/DKUM-100174 Vpliv heterologne sklopitve na sinhronizacijo kalcijevih oscilacij celic alfa in beta magistrsko delo The effect of heterologous coupling on the synchronization of calcium oscillations of alpha and beta cells Preučujemo vpliv homolognih in heterolognih interakcij na sinhronizacijo počasnih kalcijevih oscilacij celic alfa in beta v Langerhansovem otočku. Analiza predhodno izmerjenih kalcijevih signalov je pokazala počasnejšo in bolj usklajeno aktivnost celic beta ter hitrejšo in bolj raznoliko aktivnost celic alfa. Ker iz meritev ni mogoče določiti smeri medceličnih vplivov, smo uporabili tridimenzionalni fazni model z ločenimi sklopitvami znotraj obeh populacij in med njima. Rezultati kažejo, da heterologna vpliva tvorita povratno zanko. Celice beta povečajo fazno urejenost in funkcionalno povezanost celic alfa, njihov spremenjeni odziv pa povratno vpliva na efektivno frekvenco celic beta in fazno razmerje med populacijama. We examine how homologous and heterologous interactions affect the synchronization of slow calcium oscillations in alpha and beta cells of the islet of Langerhans. Analysis of previously acquired calcium signals revealed slower and more coordinated activity in beta cells and faster, more heterogeneous activity in alpha cells. Because the direction of intercellular influences cannot be determined from the measurements alone, we used a three-dimensional phase model with separate couplings within and between the two populations. The results show that the heterologous interactions form a feedback loop: beta cells increase the phase order and functional connectivity of alpha cells, whose altered response subsequently affects the effective frequency of beta cells and the phase relationship between the populations. Langerhansovi otočki celice alfa celice beta kalcijeve oscilacije heterologna sklopitev islets of Langerhans alpha cells beta cells calcium oscillations heterologous coupling true true false [G. Goričan] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2026-09-07 12:20:26 2026-09-17 10:04:35 2026-09-18 03:09:56 0000-00-00 00:00:00 2026 0 Maribor 0 Maribor 43 str. 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577:576.32/.36:616.379(043.2) 291387651 MAG_Gorican_Gorazd_2026.pdf MAG_Gorican_Gorazd_2026.pdf 1 0C16854A24FF2B7F42B90CEEA39719E0 35ac150960e95269c9f2d8b9482c491aa4a8d4a564214105caca20424f96083d ce22c8ec-aab2-11f1-ba3a-00155d0001be https://dk.um.si/Dokument.php?lang=slv&id=211767 Fakulteta za naravoslovje in matematiko 0 0 0