20.500.12556/DKUM-11375 DOLOČANJE ANTITUMORSKE AKTIVNOSTI NEKATERIH KETONUKLEOZIDOV THE DETERMINATION OF ANTITUMOUR ACTIVITY IN SOME OF THE KETONUCLEOSIDES Ugotavljali smo odzivnost oziroma rast Caco-2 celic in toksicni vpliv ketonukleozidnih derivatov ter 5-FU. Pri testiranju smo uporabili tri razlicne ketonukleozidne substance v razlicnih koncentracijah in kontrolno 5- FU. Ucinkovina 1,5-Di-O-4-flour-2-N4 benzoil citozin-6-troponin je delovala toksicno in zavirala rast pri koncentracijah; 0,1 mg/mL, 0,05 mg/mL ter pri 0,025 mg/mL. Toksicno zaviralno je delovala tudi ucinkovina 1,3-Di-O-4-flour-2-N4-benzoil citozin-6-troponin pri koncentracijah; 0,1 mg/mL, 0,05 mg/mL, 0,025mg/mL, 0,0125 mg/mL. Prav tako je zavirala kontrolna ucinkovina 5-FU rast, saj je vecina celic propadla. We were establishing the response and growth of Caco-2 cells, and the toxical influence of ketonucleosideal derivates and 5-FU. At testing we used three different ketonucleosideal substances in different concentrations, and controlling 5-FU. Compound 1,5-Di-O-4-flour-2-N4 benzoyl cytozin-6- trophonine had influenced toxically and retard the growth at concentrations; 0,1 mg/mL, 0,05 mg/mL, 0,025 mg/mL. Toxical retardation was also caused by the compound 1,3-Di-O-4 -flour -2- N4 benzoyl cytozin-6-trophonine at concentrations; 0,1 mg/mL, 0,05 mg/mL, 0,025mg/mL, 0,0125 mg/mL. The controlling compound 5-FU were retarded growth, and most of the cells died. Kljucne besede: ketonukleozidi / nukleozidni analogi / antitumorska aktivnost / Caco-2 celice / celicne kulture / gojišca Keywords: ketonucleosides / nucleosideal analogues / antitumour activity / Caco-2 cells/ cell culture/ culture media true true false Slovenski jezik Angleški jezik Diplomsko delo 2009-08-17 18:43:39 2009-09-01 08:22:48 2022-04-11 23:47:28 2022-04-18 03:09:50 2009 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 URN:SI:UM:DK:HY7VYW3Y UNI_Vodenik_Tomaz_2009.pdf UNI_Vodenik_Tomaz_2009.pdf 1 11FB0F129F1AD2FB2D5E413942BCF060 810dda9ff28b0f9082d32a42dea504c2b9ba3fb4e33cc6ee684b55a8ebc372b9 1a702d8d-7c03-11eb-bb7a-00155d0001ca 20.500.12556/dkum/87078edc-748c-4022-b0cd-a5e7b4ef4dff https://dk.um.si/Dokument.php?lang=slv&id=10074 Fakulteta za kmetijstvo in biosistemske vede 0 0 0