20.500.12556/DKUM-13046 SKLADIŠČENJE IN STABILNOST VITAMINOV TER DOLOČANJE VSEBNOSTI RETINOL PALMITATA VITAMINE STORAGE, STABILITY AND DETERMINATION OF RETINOL PALMITATE CONTENT Diplomska naloga obsega pregled vitaminov — čistih substanc, ki se uporabljajo v farmacevtski proizvodnji. Zbrali smo varnostne liste, certifikate in analizne izvide za vitamine, ki jih uporabljamo pri proizvodnji vitaminskih izdelkov v Krkinem obratu Ljutomer. Rezultate za vsebnost vitaminov in roke uporabnosti smo primerjali iz certifikatov in iz Krkinih analiznih izvidov. Primerjali smo predpise za skladiščenje vitaminov po varnostnih listih, etiketah in drugi literaturi in ugotavljali dejansko upoštevanje predpisanih priporočil in navodil za skladiščenje. Iz različnih virov literature in iz specifikacij o vitaminih, smo v nalogi navedli vplive na stabilnost vitaminov. Za vitamin A, retinol palmitat smo naredili preskuse in ugotovili, kako vpliva segrevanje, svetloba, vlaga in hranjenje vitamina v neoriginalni embalaži na stabilnost vitamina. Potrdili smo, da sta hranjenje in skladiščenje pomembna dejavnika za stabilnost vitaminov. SUMMARY Diploma includes vitamins overview – pure substances which are used in pharmaceutical industry in production. We have collected Safety Data Sheets, Certificats and Analytic reports for vitamins, which we are used in the manufacture of vitamin products in Krka, Ljutomer plant. Vitamins contens results and expiration dates were comapared to certificates and Krka anlityc sheets. We have compared vitamins storage regulations according to Safety Data Sheets, labels and other literature sources and we were determining actual consideration of prescribed references and storage instruction usage. From various sources of literature and specification data we listed impacts on stability of vitamins. For vitamin A, retinol palmitate we have made tests and determine how heating, light, moisture and storage of the vitamin in non original packaging effects on vitamins stability. We have confirmed that storage and vitamins packaging are important factors in stabilty of vitamins. Ključne besede: vitamini skladiščenje stabilnost vsebnost retinol palmitat spektrofotometrija varnostni list certifikat analizni izvid. vitamins storage stabilitiy content renitol palmitate spektrophotometry Safety Data Sheet Certificate Analitic reports. true true false [A. Rožman] Slovenski jezik Angleški jezik Diplomsko delo 2010-01-24 19:15:20 2010-03-02 11:30:34 2022-04-12 08:01:37 2022-04-20 03:27:11 2009 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 665.112(043.2) 13440278 URN:SI:UM:DK:N3UAM6GY VS_Rozman_Anica_2010.pdf VS_Rozman_Anica_2010.pdf 1 2AF37E6DAFC7F72128DE8C3B3AF75A00 6ceac512979aaf86ce8d8f549965af6df381c10e8ba267700ff8fe18ad0119e7 cde972cf-7c03-11eb-bb7a-00155d0001ca 20.500.12556/dkum/7ed47849-3857-404b-85df-dde184700aeb https://dk.um.si/Dokument.php?lang=slv&id=12886 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0