20.500.12556/DKUM-15475 SINTEZA IN UPORABA ORGANSKIH BIORAZGRADLJIVIH AEROGELOV KOT NOSILCEV AKTIVNIH UČINKOVIN SYNTHESIS AND APPLICATION OF BIODEGRADABLE ORGANIC AEROGELS AS DRUG CARRIERS Naravni polimeri so se uveljavili kot obetaven material za sintezo in pripravo nanoporoznih delcev. Eden izmed najbolj raziskanih in uporabljenih naravnih polimerov je alginat, ki ga pridobivajo iz različnih vrst rjavih morskih alg. Zaradi sposobnosti geliranja in nabrekanja ter nekaterih drugih lastnosti je zelo primeren kot nosilec aktivnih učinkovin. V diplomski nalogi smo pripravili 1,5%; 2% in 2,5% alginatne gele: monolite, ki smo jih narezali na koščke in sferične alginatne kroglice, v katere smo vezali nikotinsko kislino kot aktivno substanco. Nato smo jih superkritično posušili s CO2 in tako dobili organske biorazgradljive aerogele. Natural polymers have established themselves as a promising material for the synthesis and preparation of nanoporous particles. One of the most researched and used natural polymers is alginate, which is obtained from different types of brown seaweed. Due to its ability to gel and swell and some other properties, alginate is very suitable as a carrier for active ingredients. In this thesis, we prepared 1.5%, 2% and 2.5% alginate gels: monoliths, which were cut into small pieces and spherical alginate beads, in which we introduce nicotinic acid as active substance. We then dried by supercritical CO2 and thus obtained biodegradable organic aerogels. alginat aerogeli nikotinska kislina škrob superkritično sušenje nadzorovano sproščanje. alginate aerogels nicotinic acid starch supercritical drying controlled release. true true false [T. Fajfar] Slovenski jezik Angleški jezik Diplomsko delo 2010-09-09 11:00:22 2010-09-10 12:46:23 2022-04-12 22:52:40 2023-12-19 03:18:07 2010 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 544.774.2-961(043.2) 14995990 URN:SI:UM:DK:DW062KHQ UNI_Fajfar_Tanja_2010.pdf UNI_Fajfar_Tanja_2010.pdf 1 55AF2A708AEA2F1E79256F26510E7185 9ae1a2332aab5ad007f4a5ec2421038d7f841857c67b0faec3d14e3acd721b61 6898e6a8-7c04-11eb-bb7a-00155d0001ca 20.500.12556/dkum/19d7b4f1-99ab-4aaf-a209-952779e24fdd https://dk.um.si/Dokument.php?lang=slv&id=17027 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0