20.500.12556/DKUM-15890 RAZVOJ IN VALIDACIJA POLAROGRAFSKE METODE ZA DOLOČANJE VSEBNOSTI SLEDOV TIOSULFATA V FARMACEVTSKIH UČINKOVINAH DEVELOPMENT AND VALIDATION OF POLAROGRAPHIC METHOD FOR THIOSULPHATE DETERMINATION IN PHARMACEUTICAL PRODUCTS Namen diplomske naloge je bilo razviti in validirati polarografsko metodo za določanje vsebnosti sledov tiosulfata v farmacevtskih učinkovinah, ki sodijo v kemijsko skupino prazolov. Tiosulfat se pojavlja v sintezni shemi kot nečistota. Vsebnost tiosulfata smo določali z uporabo diferencialno pulzne polarografije (DPP) in kapljajoče živosrebrne elektrode (KŽE). Za nosilni elektrolit smo uporabili fosfatni pufer pH 6,0. Sledove smo iskali v šestih različnih realnih vzorcih. Opravili smo validacijo analizne metode, določili smo linearnost, točnost, natančnost, ponovljivost, mejo zaznave, mejo določanja in stabilnost. Iz rezultatov je razvidno, da so sledovi tiosulfata vidni samo pri dveh vzorcih. Dokazali smo, da je analizna metoda primerna in uporabna za določanje tiosulfata v farmacevtskih učinkovinah. Purpose of this diploma thesis was to develop and validate the polarographic method for thiosulphate determination in pharmaceutical substances, which belong to the chemical group called prazols. In the synthesis scheme the thiosulphate appears as an impurity. We have determined its content with differential pulse polarography (DPP) and dropping mercury electrode (DME). Phosphate buffer pH 6,0 has been used as the supporting electrolyte. We have analysed six different real samples. We have validated the analytical method, determinated the linearity, accuracy, precision, repeatability, limit of detection, limit of quantification and stability. Thiosulphate traces were found in only two of the samples. We have concluded that this analytical method is appropriate and useful for the thiosulphate determination in pharmaceutical substances. voltametrija polarografija diferencialno pulzna polarografija živosrebrna kapljajoča elektroda tiosulfat prazoli validacija zaviralci protonske črpalke. voltammetry polarography differential pulse polarography dropping mercury electrode thiosulphate prazols validation proton pump inhibitors. true true false [N. Mugoša] Slovenski jezik Angleški jezik Diplomsko delo 2010-09-23 13:41:35 2010-10-01 07:48:06 2022-04-13 07:41:24 2023-12-19 03:37:22 2010 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 543.454(043.2) 14996758 URN:SI:UM:DK:9UVIGNK1 UNI_Mugosa_Nina_2010.pdf UNI_Mugosa_Nina_2010.pdf 1 A0C0B0AA86F76D75805D3A13E9A7537C a1b8243d8b33a9d670b82bbeafc648a0dd349d75135c7b7d1b9022a25b07a4e4 835ed2eb-7c04-11eb-bb7a-00155d0001ca 20.500.12556/dkum/c5bad6f3-6168-4b1d-ad0b-15a797e32b62 https://dk.um.si/Dokument.php?lang=slv&id=17722 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0