20.500.12556/DKUM-17423 Preparation of enantiomers using high pressure technologies Priprava enantiomer z uporabo visokotlačnih tehnologij The study of two different methods of obtaining chiral alcohols is proposed herein. The requirement of the relatively new paradigm of green chemistry associated with clean technologies such as biocatalysis or non-conventional solvents, dense gases, was focused at. Indeed, the two methods of production of chiral alcohols were: - the conversion of acetophenone into (R)-1-phenylethanol in dense gases catalysed by Lactobacillus brevis alcohol dehydrogenase and its coenzyme, NADP/H; - the resolution of (±)-trans-1,2-cyclohexanediol by cocrystal formation with tartaric acid followed by supercritical extraction. In both cases high enantiopurities were achieved (ee>99%). V študiji sta podani dve različni metodi za pridobivanje kiralnih alkoholov. Doktorsko delo je osredotočeno predvsem na orodja »zelene kemije«, ki so povezana s čistimi tehnologijami kot sta biokataliza ali nekonvencionalna topila in zgoščeni plini. Obe metodi za pridobivanje kiralnih alkoholov se navezujeta na: - Presnovo acetofenona v (R)-1-feniletanol v zgoščenem plinu, katalizirano z alkohol dehidrogenazo iz Lactobacillus brevis in koencimom, NADP/H; - Resolucijo (±)-trans-1,2-cikloheksandiola v obliki nastajanja kokristala s tartarno kislino in s superkritično ekstrakcijo. V obeh primerih je bil izkoristek pridobivanja enantiomerno čistih komponent zelo visok (ee>99%). High-pressure technologies enantiomers green chemistry R-1-phenylethanol Lactobacillus brevis alcohol dehydrogenase NADP liquid propane enzyme deactivation resolution trans-1 2-cyclohexanediol tartaric acid cocrystal supercritical carbon dioxide extraction X-ray diffraction differential scanning calorimetry Visokotlačne tehnologije enantiomere zelena kemija R-1-feniletanol Lactobacillus brevis alkohol dehidrogenaza NADP tekoči propan deaktivacija encima resolucija trans-1 2-cikloheksandiol tartarna kislina kokristal superkritični ogljikov dioksid ekstrakcija rentgenska difrakcija (XRD) termična (DSC) analiza true true false [P. Thorey] Angleški jezik Slovenski jezik Doktorska disertacija 2011-02-02 08:11:09 2011-02-02 08:19:41 2022-04-13 09:29:26 2023-12-22 03:27:03 2010 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 66-987:544.122.3(043.3) 14769942 URN:SI:UM:DK:EEHKUWVK DR_Thorey_Paul_2011.pdf DR_Thorey_Paul_2011.pdf 1 35BA1C8653BBD9C7B00377352C02F2A4 411c74d95890de13266d4cd64789da6c4cfb8cca0ed97726f713590d62e800d4 e2fb37d9-7c04-11eb-bb7a-00155d0001ca 20.500.12556/dkum/52d3f311-743b-4437-8089-2bc9e0359f94 https://dk.um.si/Dokument.php?lang=slv&id=20318 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0