20.500.12556/DKUM-17728 VPLIV IMATINIB MESILATA NA DELOVANJE TIROZIN KINAZ RAKASTIH CELIC PRI KRONIČNI MIELOIČNI LEVKEMIJI IMPACT OF IMATINIB MESILATE ON TYROSINE KINASES OF CANCER CELLS IN CRONIC MYELOGENOUS LEUKEMIA Namen diplomske naloge je raziskati uspeh zdravljenja bolnikov s kronično mieloično levkemijo, in sicer z imatinib mesilatom, ki deluje kot inhibitor tirozin kinaz. V ta namen smo preučili laboratorijske izvide sedmih bolnikov. Določili smo krvno sliko z razmazom, na podlagi katere smo nato ugotovili diagnozo, in prisotnost kromosoma Philadelphia, ki diagnozo potrdi, pri čemer njegova neprisotnost pri zdravljenju pomeni citogenetsko remisijo. Ugotavljali smo še prisotnost BCR-ABL onkogena, saj neprisotnost BCR-ABL onkogena iz bolnikove krvi pomeni molekularno remisijo, kar pomeni popolno ozdravitev. Ugotovili smo, da se je zdravljenje izkazalo za zelo uspešno. Pri treh bolnikih smo dosegli glavni molekularni odgovor, pri dveh popolni molekularni odgovor, pri enem popolni citogenetski odgovor. En bolnik se na zdravljenje z imatinib mesilatom ni odzval. The purpose of this thesis is to research treatment success in cases of patients with a chronic myelogenous leukemia with the tyrosine kinases inhibitor imatinib mesilate. For this purpose, we examined the laboratory findings of seven patients. We defined the blood count with a spread, on the basis of which we established the diagnosis, and the occurance of Philadelphia chromosome, which confirms the diagnosis, while its absence in treatment signifies the cytogenetic remission. In addition, we also determined the presence of BCR-ABL oncogene where the absence of BCR-ABL oncogene in patient´s blood indicates the molecular remission, which signifies complete recovery. We found out that this treatment proved to be very successful. In case of three patients we attained the major molecular response, two of them reached complete molecular response, and one complete cytogenetic response. One patient did not accede to treatment with imatinib mesilate. kinaza levkemija levkociti imatinib kinase leucocytes leukemia imatinib true true false [P. Rošker] Slovenski jezik Angleški jezik Diplomsko delo 2011-03-14 09:28:35 2011-03-24 12:58:15 2022-04-13 09:45:12 2023-12-22 03:43:53 2011 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.155.392:579(043.2) 15151126 URN:SI:UM:DK:R4DYQPBT UNI_Rosker_Petrina_2011.pdf UNI_Rosker_Petrina_2011.pdf 1 76F4CBA7C702CEB165E94E5F405AE527 6efb81cb2f77cd5a01d28ebf0fd8b7187ac1f50e2b9e2e7ba35697a3130d98e3 f5998621-7c04-11eb-bb7a-00155d0001ca 20.500.12556/dkum/692eede3-dc40-4d4e-8950-c8e47198272e https://dk.um.si/Dokument.php?lang=slv&id=20828 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0