20.500.12556/DKUM-20878 FUNKCIONALIZACIJA CELULOZE S HITOZANOM IN NJEGOVIMI DERIVATI FUNCTIONALIZATION CELLULOSE WITH HITOSAN AND ITS DERIVATIVES Medicinske tekstilije so eno od najhitreje rastočih področij tehničnih tekstilij. Hiter razvoj je mogoče pripisati različnim dejavnikom kot so naraščanje in staranje prebivalstva, sprememba ţivljenjskega standarda in povečan pomen zdravega ţivljenja ter skrbi za zdravje, pa tudi zaradi porasta bakterijsko nalezljivih bolezni in bolnišničnih okuţb. Za doseganje protimikrobnih lastnosti tekstilnih materialov obstajajo številne metode funkcionalizacij. Pri večini teh metod se še zmeraj uporabljajo reagenti, ki so človeku in okolju neprijazni, saj lahko vsebujejo anorganske soli, fenole in tiofenole, antibiotike, derivate formaldehida, itd. Zaradi tega v zadnjem času narašča zanimanje za funkcionalizacijske postopke pri katerih se uporabljajo okolju prijazni in biorazgradljivi reagenti, kot so do sedaj manj uporabljeni aminski polisaharidi in njihovi derivati, ki posedujejo protimikrobne lastnosti. Med njimi je trenutno najbolj aktualen aminski polisaharid hitozan, ki pa kljub zelo aktualni in široki uporabnosti izkazuje nekatere slabosti, zlasti omejeno topnost, ter posledično protimikrobno aktivnost le v kislem mediju. Iz hitozana je mogoče s kemičnimi modifikacijami pridobiti širok spekter derivatov z namenov izboljšave njegovih lastnosti. Namen naloge je bil izvesti primerjavo med komercialnim hitozanom (primarne aminske skupine) in njegovim derivatom (hitozan s kvarternimi amonijevimi spojinami) z vidika potencialne uporabnost hitozana kot adsorbata za funkcionalizacijo površin tekstilij. Izvedeni so bili postopki adsorpcije hitozana iz tekočega medija na površino celuloze. Funkcionalizirana celulozna vlakna so okarakterizirana s fizikalno-kemijskega (določitev funkcionalnih skupin vlaken) kot tudi protimikrobnega značaja. Ugotovili smo, da se kvarterni hitozan v primerjavi s komercialnim (aminske skupine) na površino vlaken adsorbira v večji količini in ima večjo vsebnost dostopnih aminskih skupin ter tako daje posledično boljše protimikrobne učinke. Medical textiles are one of the fastest growing fields of technical textiles. This fast development can be attributed to several factors such as: population growth and age, life standard changes and increased awareness of healthy living and concern for health, as well as increase in contagious bacterial diseases and hospital infections etc. Several functionalization methods for acquiring antimicrobial qualities of textile materials are available. Most of these methods still employ reagents harmful to humans and the environment, and they include inorganic salts, phenols and thiophenols, antibiotics, formaldehyde etc. That is why the use of functionalization procedures, which use environmentally friendly and biodegradable reagents, such as amino polysaccharides and their derivatives with antibacterial qualities, has been increasing. At this time, the most commonly used is the amino polysaccharide chitosan. But despite of its common and widely spread use it shows certain drawbacks, especially limited solubility and, consequently, antimicrobial activity only in an acidic medium. A broad spectrum of derivatives can be gained from chitosan by using chemical modifications with the purpose of improving its characteristics. The purpose of this thesis is to carry out a comparison between the commercial chitosan (primary amino groups) and its derivatives (chitosan with quaternary ammonia compounds) regarding potential use of chitosan as an adsorbate for fuctionalization of textile surfaces. We performed procedures of chitosan adsorption from a liquid medium to the cellulose surface. The physical-chemical (determining the functional group of the fibres) and antimicrobial properties of functionalized cellulose fibres have been characterised. We concluded that quaternary chitosan, if compared to the commercial chitosan (amino groups), adsorbs a larger quantity on the fibre surface and has a higher content of available amino groups and consequently better antimicrobial effects. viskoza aminski polisaharidi funkcionalizacija hitozan kvarterni hitozan protimikrobne lastnosti chitosan quaternary chitosan antimicrobial properties functionalized viscose true true false [P. Slemnik] Slovenski jezik Angleški jezik Diplomsko delo 2011-10-05 22:49:22 2011-10-07 14:15:48 2022-04-14 08:20:53 2023-12-27 03:09:33 2011 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 677.2.017(043.2) 16022294 URN:SI:UM:DK:K0YDG8JD UNI_Slemnik_Petra_2011.pdf UNI_Slemnik_Petra_2011.pdf 1 4BA2ED1D9AE7C736BAFEAD61C83D2DCF 96894df7561d040bd8c685b55f17e5eb45c35adafa939297d23271b562e6ded6 b9c39209-7c05-11eb-bb7a-00155d0001ca 20.500.12556/dkum/d2fbcc51-c63f-4d46-b2b1-390932fa9d5f https://dk.um.si/Dokument.php?lang=slv&id=26186 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0