20.500.12556/DKUM-25996-cdf548a0-516a-c8b8-98ed-0a69fa0bd197 Supercritical fluid extraction of chammomile flower head flowers: comparison with conventional extraction, kinetics and scale-up Supercritical fluid extraction of chamomile flower heads was performed on semicontinuous extraction apparatus in the lab scale using carbon dioxide as solvent. The results of high pressure experiments were compared with those obtained with Soxhlet extraction, steam distillation and maceration. The obtained extracts were analysed by HPLC on ?-bisabolol, matricine and chamazulene content and by gravimetrical method on essential oil and waxes content. The highest content of active components in extracts and highest extraction yield were obtained using SFE at 250 bar and 40 °C. At this extraction conditions the two step separation was used to optimize the separation of essential oil from unwanted components. Dynamic behaviour of theSFE with single step separation runs were analysed using two mathematical models for describing the constant rate period and subsequent falling rate period. Based on the experimental data, external mass transfer coefficient, diffusion coefficient and diffusivity in solid phase were estimated. Results showed acceptable agreement of calculated and experimental data. Based on theparameters determined in the lab scale, the extraction process was successfully transferred to pilot scale. chemical processing high pressure technology supercritical extraction chamomile matricine chamazulen scale-up kemijska procesna tehnika visokotlačna tehnologija ekstrakcija kamelice true false false Angleški jezik Angleški jezik Neznano 2012-05-31 11:38:09 2012-05-31 11:38:09 2023-08-16 14:40:18 2023-12-31 03:30:27 2007 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 66.061-987 11754262 0896-8446 URN:SI:UM:DK:00DEEII4 http://dx.doi.org/10.1016/j.supflu.2007.02.005 1 https://dk.um.si/Dokument.php?lang=slv&id=34893 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0