20.500.12556/DKUM-26580 Zastosowanie pomiarów konduktometrycznych w ocenie potencjalnego pulsacyjnego uwalniania chlorowodorku lidokainy z termowrażliwych mikrożeli na bazie N-izopropyloakryloamidu The use of conductometric assessments for development of pulsed release of lidocaine hydrochloride from thermosensitive N-isopropylacrylamide microgels The aim of present work was preliminary assessment of the conductivity changes in aqueous compartment, consisting of lidocaine hydrochloride, and N-isopropylacrylamide derivative microgel, during increasing the temperature between 25° and 42°C, as a prerequisite to demonstrate the possibility of applying this microgel for pulsed release of lidocaine hydrochloride, when increased temperature is applied. Conductivity of respective systems composed of polymer and lidocaine hydrochloride were assigned as PNM I-LD, PNM II-LD, and PNM III - LD: obtained values were in the ranges: 39,91 muS/cm - 53,30 muS/cm in the 25°C temperature, 46,14 muS/cm - 56,16 muS/cm in the temperature of 32°C, and 53,30 muS/cm - 118,42 muS/cm at 42°C. During heating or cooling of the microgels derivatives of N-isopropylacrylamide, there is possibility to obtain pulsed release of lidocaine hydrochloride from the polymeric bead in the range between 25°C and 42°C, according to the conductivity measurements. lidocaine hydrochloride microgels N-isopropylacrylamide pulsed release thermosensitivity conductivity true true false Slovenski jezik Angleški jezik Neznano 2012-05-31 14:01:52 2012-05-31 14:01:52 2022-04-15 03:42:06 2024-01-03 03:32:00 2009 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 677.017:543 14721302 0370-0747 URN:SI:UM:DK:SSCZSSGF http://www.polimery.am.wroc.pl/2009/402a.pdf 1 https://dk.um.si/Dokument.php?lang=slv&id=35643 Fakulteta za strojništvo 0 0 0