20.500.12556/DKUM-26725 Wpływ polimeru jonowego i niejonowego na odczyn preparatów lidokainy w temperaturze poniżej i powyżej temperatury powierzchni skóry ludzkiej Effect of ionic and non-ionic polymer on the pH of lidocaine hydrochloride preparation assessed below and over human skin surface temperature Lidocaine is widely accepted local anesthetic, which is applied in the form of freely soluble hydrochloride salt. In this study we evaluated the pH of respective solutions of lidocaine hydrochloride with ionic polymer - polyacrylic acid or non-ionic polymer - methylcellulose, and compared to physiological skin conditions in the range between 22°C and 41°C. In microscopic observation of lidocaine hydrochloride preparations with polyacrylic acid the micro-sedimentation was revealed, however obtained mixture was opalescent, and homogenously dispersed in aqueous environment. The pH was maintained on the level not higher then 4,0 in the period of 12 hours for polyacrylic acid formulation, whereas in the case of preparation with methylcellulose, the pH increased from acceptable pH of ca. 4,5 to the level of above 6,0. The polyacrylic acid derivatives should be further studiedas vehicles forming preparations with stable pH value during application on the skin, with more specific methods including pH microelectrodes, sufficient for assessments in small quantities of liquids of skin surface. lidocaine hydrochloride polyacrylic acid methylcellulose pH true true false Slovenski jezik Angleški jezik Neznano 2012-05-31 14:49:05 2012-05-31 14:49:05 2022-04-15 03:42:25 2024-01-03 03:35:01 2010 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 677.017:543 14722070 0370-0747 URN:SI:UM:DK:YXZQHHJG http://www.polimery.am.wroc.pl/pdf/107.pdf 1 https://dk.um.si/Dokument.php?lang=slv&id=35833 Fakulteta za strojništvo 0 0 0