20.500.12556/DKUM-26820 Use of AFM force spectroscopy for assessment of polymer response to conditions similar to the wound, during healing Uporaba AFM-spektroskopije sil za spremljanje odziva polimernih molekul na v rani podobna okolja med celjenjem Force spectroscopy is a very promising technique for the evaluation of interactions within different environments. Knowledge about them is especially important during the design and preparation of those modern wound dressings in contact with a changing wound-environment over a prolonged time. Such exposure can cause a drastic decrease in the materialćs mechanical performance, and can lead to degradation, thus lowering the success of any healing process. Our study tries to establish a model system, which would enable us to assess the applicability of the mentioned technique for the evaluation of any interaction changes between polymer molecules and a chosen surface, after exposure to different environments. Our proposed experimental setup consists of two representative polymers, a model silicon surface, and two solutions of various pHs and ionic strengths, respectively. Within the chosen range of parameters, we are confident that we can prove the usefulness of force spectroscopy for further research into polymer suitability, for the development of novel wound dressings. Spektroskopija sil je zelo obetavna tehnika za uporabo pri določanju interakcij v številnih različnih okoljih. Poznanje le-teh je še posebej pomembno pri načrtovanju in pripravi novodobnih obližev, ki morajo biti v stiku z rano dalj časa in so tako izpostavljeni spreminjajočemu se okolju. To lahko na samem materialu povzroči drastične spremembe in vodi v otežen potek celjenja. V tem delu smo želeli pripraviti modelni sistem, s katerim bi preverjali možnost uporabe omenjene tehnike za ugotavljanje sprememb interakcij med polimernimi molekulami ter izbrano površino po izpostavitvi različnim okoljem. Eksperimentalni sistem je vseboval dva vzorčna polimera, modelno silicijevo površino ter po dve raztopini z različnimi pH in ionskimi močmi. S takim naborom parametrov smo zajeli dovolj možnosti za ugotovitev uporabnosti tehnike za nadaljnje raziskave primernosti polimernih materialov za nove obliže. force spectroscopy AFM wound dressings polymer materials model system spektroskopija sil mikroskopija na atomsko silo obliži polimerni materiali modelni sistem true false true Angleški jezik Slovenski jezik Znanstveno delo 2012-06-01 08:17:00 2012-06-01 08:17:00 2022-04-15 13:33:44 2024-01-04 03:10:21 2011 0 0 str. 259-263 št. 3 Letn. 45 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1580-2949 533.53:678 106193664 14986262 1580-2949 URN:SI:UM:DK:GTPPTYKU Materiali_in_Tehnologije_2011_Maver_et_al._Use_of_Afm_Force_Spectroscopy_for_Assessment_of_Polymer_Response_To_Conditions_Similar_To_the.pdf Materiali_in_Tehnologije_2011_Maver_et_al._Use_of_Afm_Force_Spectroscopy_for_Assessment_of_Polymer_Response_To_Conditions_Similar_To_the.pdf 1 38C245A2A2E64255B1EC4D1D5B189246 f1d9897ece00c18a300c95f7a338d8b7b1892f00961ef8487d7918f500016dff 04e0db4b-7c0e-11eb-bb7a-00155d0001ca 20.500.12556/dkum/9dec9216-3d32-4bc8-9a01-b126e222c141 https://dk.um.si/Dokument.php?lang=slv&id=110152 http://www.imt.si/Revija/izvodi/mit113/maver_U.htm 1 https://dk.um.si/Dokument.php?lang=slv&id=35969 Fakulteta za strojništvo 0 0 0