20.500.12556/DKUM-31149 The quest for genetic risk factors for Crohn's disease in the post-GWAS era Multiple genome-wide association studies (GWASs) and two large scale meta-analyses have been performed for Crohn's disease and have identified 71 susceptibility loci. These findings have contributed greatly to our current understanding of the disease pathogenesis. Yet, these loci only explain approximately 23% of the disease heritability. One of the future challenges inthis post-GWAS era is to identify potential sources of the remaining heritability. Such sources may include common variants with limited effect size, rare variants with higher effect sizes, structural variations, or even more complicated mechanisms such as epistatic, gene-environment and epigeneticinteractions. Here, we outline potential sources of this hidden heritability, focusing on Crohn's disease and the currently available data. Wealso discuss future strategies to determine more about the heritability; these strategies include expanding current GWAS, fine-mapping, whole genome sequencing or exome sequencing, and using family-based approaches. Despite thecurrent limitations, such strategies may help to transfer research achievements into clinical practice and guide the improvement of preventive and therapeutic measures. genetic risk factors Crohn’s disease genetski faktorji tveganja Crohnova bolezen true false true Angleški jezik Slovenski jezik Znanstveno delo 2012-06-05 10:23:13 2012-06-05 10:23:13 2022-04-18 14:04:22 2021-04-13 03:27:50 2011 0 0 str. 1-13 Letn. 3 2011 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1756-994X 616.344:577 512172600 10.1186/gm227 1756-994X URN:SI:UM:DK:S10E3EJ4 RAZ_Fransen_Karin_i2011.pdf RAZ_Fransen_Karin_i2011.pdf 1 EA5D22DCB1E3EFF32F5499E2B11DF2BA 067651301a7a5d8dc6315292418a3774503175d34d50483a491739663161c4a0 87cd9951-7c07-11eb-bb7a-00155d0001ca 20.500.12556/dkum/2977d8a9-f69f-4429-a1bb-dca139d401d5 https://dk.um.si/Dokument.php?lang=slv&id=41503 http://genomemedicine.com/content/pdf/gm227.pdf 1 https://dk.um.si/Dokument.php?lang=slv&id=41504 Medicinska fakulteta 0 0 0