20.500.12556/DKUM-36580 SIMULACIJE UČINKOVANJA RAZLIČNIH ZDRAVIL NA PRODUKCIJO EIKOZANOIDOV Z MODELOM PRESNOVE ARAHIDONSKE KISLINE IN APLIKACIJA NA ASPIRINSKO INTOLERANCO SIMULATIONS OF THE EFFECTS OF DIFFERENT DRUGS ON THE PRODUCTION OF EICOZANOIDS WITH THE MATHEMATICAL MODEL OF ARACHIDONIC ACID METABOLISM AND ITS APPLICATION TO ASPIRIN - INDUCED ASTHMA V diplomskem seminarju z matematičnim modelom presnove arahidonske kisline preučujemo vpliv nesteroidnih antirevmatikov (NSAR) na pojav bronhokonstrikcije pri aspirinsko intolerantnih astmatikih. Za tri različne populacije aspirinsko-intolerantnih astmatikov ocenimo, pri kateri dozi indometacina in etoricoxiba se tveganje za simptome aspirinske intolerance poveča in ocenimo, kako dolgo traja bronhokonstrikcija pri tipični terapevtski dozi indometacina. Preučujemo tudi strategijo, pri kateri aspirin, ibuprofen ali indometacin doziramo skupaj z inhibitorjem encima 5-lipoksigenaze. Ta strategija bi lahko omogočila varno doziranje nesteroidnih antirevmatikov aspirinsko-intolerantnim astmatikom brez tveganja bronhokonstrikcije. In this diploma work we studied the impact of non-steroidal anti-inflammatory drugs (NSAIDs) on the occurrence of bronchoconstriction in aspirin-intolerant asthmatic patients. For this purpose a mathematical model is used to describe the interaction between NSAID with arachidonic acid metabolism in white blood cells. We estimated, for three different populations of aspirin-intolerant asthmatic patients, at which doses of indomethacin and etoricoxib the risk of bronchoconstriction is increased. In addition, the duration of bronchoconstriction is theoretically estimated for typical therapeutic dose of indomethacin. We also study the strategy for safe managing of NSAIDs to aspirin-intolerant asthmatic patients in combination with inhibitor of the enzyme 5- lipoksigenaze (5-LOX) without risk of bronchoconstriction. matematični model arahidonska kislina nesteroidni antirevmatiki astma aspirinska intoleranca zdravila farmakokinetika mathematical model arachidonic acid non-steroidal anti-inflammatory drugs asthma aspirin intolerance asthmatic patients pharmacokinetics true true false [S. Ferk] Slovenski jezik Angleški jezik Diplomsko delo 2012-06-14 23:15:54 2012-07-16 13:51:37 2022-04-20 08:51:56 2024-01-01 03:30:28 2012 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 53(043.2) 19247624 URN:SI:UM:DK:ZZVVXDOO UNI_Ferk_Sonja_2012.pdf UNI_Ferk_Sonja_2012.pdf 1 70C851D991975B104BF7EBAB5621F9AC 43313e3b8d18a068d0846c8a7952e56b2f98ec1f97c6ca28bcffe5d36264f886 146af770-7c08-11eb-bb7a-00155d0001ca 20.500.12556/dkum/4363669a-a431-4889-8aaf-2c4b5d220148 https://dk.um.si/Dokument.php?lang=slv&id=47779 Fakulteta za naravoslovje in matematiko 0 0 0