20.500.12556/DKUM-37465 Študij postopka nanomodifikacije aktiviranih celuloznih vlaken STUDY OF NANOMODIFICATION PROCESS OF ACTIVATED CELLULOSE FIBRES Vsako leto več milijonov ljudi trpi zaradi bolezni kosti, kot posledic travme, tumorja, zloma, ali napake. Kot alternativni pristop za zdravljenje poškodovanega kostnega tkiva se uporabljajo porozna ogrodja, ki vplivajo na pospešeno formiranje kosti iz okoljskega tkiva. Tako ogrodja imajo veliko prednost pred avtografti in alografti. V sedanjm času se veliko nanomaterialov uporablja v biomedicinskih raziskavah za različne namene. Zanimiva uporaba je posnemanje naravnega tkiva in priprava primarnega ekstracelularnega okolja za rast in razvoj celic znotraj biomimetičnega materiala. Hidroksiapatit je glavna anorganska sestavina kostnega tkiva in zato je primeren za pripravo kostnih nadomestnih tkiv, vendar potrebuje primerno ogrodje. Celuloza je široko uporaben in lahko dostopen polisaharid, ki se pogosto uporablja tudi na področju medicinskih tekstilij. Biokompatibilnost celuloze je dobro raziskana, njene mehanske lastnosti se dobro ujemajo z lastnostmi trdega in mehkega kostnega tkiva. V okviru magistrske naloge smo pripravili biokompatibilen nanokompozit, tako da smo plast delcev hidroksiapatita oblikovali na tekstilni površini, ki mora prav tako zadovoljiti posebnim zahtevam medicinskih tekstilij. Uporabili smo regenerirana celulozna vlakna v obliki netkane tekstilije, ki smo jo pred postopkom nanomodifikacije še ustrezno predobdelali z namenom, da z aktivacijo vlaken zagotovimo pogoje za oblikovanje homogenih plasti delcev na površini vlaken. Vlakna smo alkalno in plazemsko predobdelali in proučili vpliv predobdelave na postopek oblikovanja nanoprevlek na vlaknih. Ugotovili smo, da je aktivacija s plazmo dobra in ekološko prijazna alternativa predobdelavi z NaOH. Razporeditev in velikost delcev nanohidroksiapatita (nHA) na vlaknih, ki so bila predobdelana s plazmo je boljše v primerjavi z vlakni, ki so bila predobdelana z NaOH. Slaba lastnost je, da postopek vpliva na mehanske lastnosti materiala. Every year, millions of people are suffering from bone defects arising from trauma, tumor or bone related diseases. Nowadays, bone tissue engineering, using a porous scaffold material to induce the formation of bone from the surrounding tissue or to act as a template to grow cell for bone tissue regeneration, has some distinct advanteges over autografting and allografting and is an alternative approach to heal damaged bone tissue. Most nanomaterials can be applied to many aspects in biomedical research. One intriguing application of nanomaterials is to mimic the natural tissues and provide the proper extracellular environment for cells to grow and survive inside the material. Hydroxyapatite is the main inorganic constituent of the bone, that’s way, it is appropriate for such applications but it needs a proper scaffold. Cellulose is widely used accessible polysaccharide, which is also widely used in the field of medical textiles. The biocompatibility of cellulose is well established. In the master thesis we prepared biocompatible nanocomposites with a layer of nanohydroxyapatite on the surface of the textile material, which must satisfy the specific requirements of medical textiles. We used regenerated cellulose fibers, which was, before the procedure of nanomodification, pre-treated in order to activate the fiber surface. With the activation we provide the conditions for forming a homogeneous layer of particles on the fibers surface. Fibers were activated by pretreatment in sodium hydroxide solution and with plasma. The effect of pretreatment on the process of creating nano-coatings on fibers was studied. The activation of fibers by plasma treatment is an eco-friendly alternative to the pretreatment with NaHO solution. Distribution and size of nHA particles on the fibers that were pre-treated with plasma is better in comparison with fibers that were pre-treated with NaOH. Kostni tkivni inženiring celuloza hidroksiapatit biokompatibilnost plazma NaOH bone tissue engineering cellulose hydroxyapatite biocompatibility plasma NaOH true true false [A. Šegula] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2012-08-31 16:51:38 2012-09-19 08:28:59 2022-04-23 23:10:30 2021-04-16 03:46:15 2012 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 677.467:620.1/.2(043.3) 16452374 URN:SI:UM:DK:R6WZCODH MAG_Segula_Adrijana_2012.pdf MAG_Segula_Adrijana_2012.pdf 1 266B96A5A796EDB02E30CC570CEB156A 3a0342b508c4e5f2d64c39fdc9e3ef27b9ee5d452f1cb00c29a2ecc4b94a5b36 3fa445cf-7c08-11eb-bb7a-00155d0001ca 20.500.12556/dkum/403fefa3-573c-4574-850d-186735eaa8ae https://dk.um.si/Dokument.php?lang=slv&id=49378 Fakulteta za strojništvo 0 0 0