20.500.12556/DKUM-41748 Fizikalno-matematični model presnove arahidonske kisline za izračun razmerij med koncentracijami eikozanoidov v primeru asprinske intolerance Mathematical model of arachidonic acid metabolism for calculation of concentration ratios between eicosanoids in case of aspirin intolerance V diplomskem seminarju obravnavamo pojav aspirinsko inducirane astme s pomočjo fizikalno-matematičnega modela presnove arahidonske kisline. Že obstoječi model nadgradimo in na podlagi razlik v ekspresiji encimov prostaglandin E sintaze (PGES) in levkotrien C4 sintaze (LTC4S) identificiramo aspirinsko intolerantne in tolerantne astmatike ter neastmatike. Modelni rezultati napovejo največje tveganje bronhokonstrikcije po zaužitju NSAR pri populaciji s povišano ekspresijo encima LTC4S in znižano ekspresijo PGES. Modelne napovedi primerjamo z izmerjenimi razmerji koncentracij med posameznimi eikozanoidi in ugotavljamo zelo dobro ujemanje modela z meritvami iz dveh različnih virov. In the graduate seminar we discuss the occurrence of aspirin-induced asthma using a mathematical model of arachidonic acid metabolism. We upgrade the existing model and based on the differences in the expressions of the enzymes prostaglandin E synthase (PGES) and leukotriene C4 synthase (LTC4S) we identify aspirin intolerant and tolerant asthmatics as well as nonasthmatics. The model predicts the highest risk of bronchoconstriction in the population in which the expression of enzyme LTC4S is increased and expression of PGES is decreased. The model results are in good agreement with the measured concentration ratios between particular eicosanoids, obtained from two different experimental studies. aspirinska intoleranca arahidonska kislina fizikalno-matematični model eikozanoidi bronhokonstrikcija nesteroidni antirevmatik (NSAR) aspirin-induced asthma arachidonic acid mathematical model eicosanoids bronchoconstriction non-steroidal anti-inflammatory drug (NSAID) true true false [N. Šilovinac] Slovenski jezik Angleški jezik Delo diplomskega seminarja/zaključno seminarsko delo/naloga 2013-09-04 10:21:50 2014-01-31 14:39:06 2022-05-05 03:08:16 2021-04-25 03:12:46 2013 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 53(043.2) 20303880 URN:SI:UM:DK:ZBH2ISUO UNI_Silovinac_Nina_2013.pdf UNI_Silovinac_Nina_2013.pdf 1 A321611AFB6E77FE3B71CC592B4F0AA5 4ae710ce956b1d738ff2664b507888781061de512c2766feb344b05b81c8af1c 3cd1ad50-7c0a-11eb-bb7a-00155d0001ca https://dk.um.si/Dokument.php?lang=slv&id=57931 Fakulteta za naravoslovje in matematiko 0 0 0