20.500.12556/DKUM-45626 PRIPRAVA BIORAZGRADLJIVIH AEROGELOV ZA POTENCIALNE FARMACEVTSKE APLIKACIJE PREPARATION OF BIODEGRADABLE AEROGLES FOR POTENTIAL PHARMACEUTICAL APPLICATIONS V diplomskem delu smo sintentizirali biorazgradljive aerogele, pripravljene iz pektina, alginata in mešanice pektin-alginat (1:1). Aerogeli so visoko porozni materiali, ki se zaradi svojih lastnosti lahko uporabljajo tudi kot potencialni nosilci aktivnih substanc. Aerogele sintentiziramo po sol-gel postopku z različnimi načini zamreženja. V našem delu smo uporabili fizikalno zamreženje z divalentnimi ioni. Preverjali smo vpliv različnih ionov (Zn2+, Ca2+ in Sr2+) na končno morfologijo aerogela in tudi na sproščanje aktivne substance. Kot modelno substanco smo uporabili diklofenak natrij. Sintentizirali smo devet tipov aerogelov. Karakterizirali smo jih s FTIRom, plinsko adsorpcijo ter preverjali njihovo nabrekanje v simulirani želodčni in prebavni tekočini. Z in-vitro testi sproščanja smo preverjali sproščanje substance. Glede na morfologijo in sproščanje substance smo ugotovili, da so najbolj primerni pektinski aerogeli, zamreženi s cinkom. Z njimi smo dobili najbolj kontrolirano sproščanje substance, v eni uri se je sprostilo okrog 40 %, v 7 h pa več kot 80 %. Potencialni nosilci bi lahko bili tudi alginatni aerogeli, zamreženi s cinkom, ki imajo podobne karakteristike kot pektinski. Kot najslabši so se izkazali aerogeli zamreženi s kalcijem. In the thesis, we synthesized a biodegradable aerogels prepared from pectin, alginate and pectin-alginate mixture (1:1). Aerogels are high porous materials that could be, due to their outstanding properties, used as potential carriers for active substances. Aerogels are synthesized by sol-gel process with the different types of cross-linking. In this thesis, physical cross-linking using divalent ions was used to prepare spherical aerogels. We examined the impact of three different ions (Zn2+, Ca2+ in Sr2+) on a final morphology of aerogels as well as on the release of the active substance. Model substance used in this work was diclofenac sodium. Nine types of aerogels were synthesized, based on three types of polysaccharides (pectin, alginate and pectin-alginate) and three types of ions (Zn2+, Sr2+ and Ca2+). Swelling experiments, nitrogen adsorption and FTIR were performed to characterize the material. Pectin aerogel, cross-linked with zinc, showed the best characteristics to control the substance release. In initial hour 40 % of the substance was released by this carrier and in the total of 7 h more than 80 % of the drug was released. Alginate aerogels, cross-linked with zinc showed similar characteristics as pectin and they could be also used to control the release of diclofenac sodium. Cross-linking with calcium turned out not to be suitable for prolonging the release of this substance. Pektin alginat aerogel diklofenak natrij biorazgradljivost Pectin alginate aerogel diclofenac sodium biodegradable true true false [M. Štumpf] Slovenski jezik Angleški jezik Diplomsko delo/naloga 2014-08-30 14:14:28 2014-09-26 10:19:49 2022-05-16 03:05:51 2021-05-02 03:32:08 2014 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 544.774.2(043.2) 18240022 URN:SI:UM:DK:D3A0TQSO UNI_Stumpf_Mitja_2014.pdf UNI_Stumpf_Mitja_2014.pdf 1 02D5B19CD162FF8B96D0DE217863DDD6 85b1a61df68023ff8aa29675ab16b358062c65d334ebd7a5837675cf83fffd27 3fb7f914-7c0b-11eb-bb7a-00155d0001ca https://dk.um.si/Dokument.php?lang=slv&id=67375 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0