20.500.12556/DKUM-47333 Povezanost kliničnih kazalcev uspešnosti zdravljenja astme pri odraslih z nukleotidnimi polimorfizmi Association of clinical parameters of asthma treatment outcome in adults with single nucleotide polymorphisms Naši rezultati nakazujejo na podlagi polimorfizov rs9910408 v genu TBX21 in rs37973 v genu GLCCI1 možnost identifikacije bolnikov, ki se bodo boljše ali slabše odzvali na zdravljenje z IGK, kar bi lahko bilo v prihodnosti klinično pomembno. Polimorfizem rs9910408 v genu TBX21 smo povezali tako s porastom FEV1, kot z zmanjšanjem bronhialne preodzivnosti (porastom PD20 za metaholin) in izboljšanjem kvalitete življenja, prikazane s spremembo rezultata vprašalnika AQLQ. Ta odziv je bil izraziteje prisoten pri nekadilcih in neatopikih. To je doslej edini opis takšne povezanosti pri odraslih bolnikih z astmo. S porastom FEV1 smo povezali tudi polimorfizem rs37973 v genu GLCCI1, pri katerem ugotavljamo velik vpliv kajenja in atopije na terapevtski odgovor. This is the first report describing the association of rs9910408 polymorphism in the TBX21 gene with improvement of bronchial hyperresponsiveness, FEV1, and quality of life in adult asthmatics treated with ICS. Our results suggest that genotyping for rs9910408 may allow the identification of patients that are more or less likely to respond to ICS therapy. In our study, treatment response to ICS (increase of FEV1) was also associated with rs37973 in GLCCI1, but smoking and atopy have great influence on genotype dependent treatment response. astma odrasli fenotip FEV1 bronhialna preodzivnost /bronhialna hiperreaktivnost polimorfizmi posameznih nukleotidov GLCCI1 CRHR1 TBX21 ACT (Asthma Control Test) AQLQ (Asthma Quality of Life Questionnaire) asthma adults phenotype FEV1 bronchial hyperresponsiveness / airway hyperresponsiveness single nucleotide polymorphisms GLCCI1 CRHR1 TBX21 ACT (Asthma Control Test) AQLQ (Asthma Quality of Life Questionnaire). true false false Slovenski jezik Angleški jezik Doktorsko delo/naloga 2015-02-05 11:17:51 2015-04-21 13:50:18 2022-05-20 03:07:49 2021-05-06 03:26:54 2015 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 512486456 URN:SI:UM:DK:02CTI5LA DOK_Lopert_Anton_2015.pdf DOK_Lopert_Anton_2015.pdf 1 A10753EBB7EC6A1762AF91AEAC54237A 48640754e026cd2026c2c1cda52731182a5609cbc45f3f626a2a9c01eabdc1a2 9be8e789-7c0b-11eb-bb7a-00155d0001ca https://dk.um.si/Dokument.php?lang=slv&id=71335 Medicinska fakulteta 0 0 0