20.500.12556/DKUM-49647 Application of gut cell models for toxicological and bioactivity studies of functional and novel foods The concept of functional and novel foods undoubtedly bears great potential as an asset to human health. However, this very same quest for ever new bioactive ingredients calls for reliable and distinct risk assessment as they may be potentially hazardous to human health. Most of today's methodologies still rely on decades old routines of animal trials and use of tumor-derived cell lines. Since such methodologies are not in line with the actual processesin the human body and with the 3R (replacement, reduction, refinement) concept, the results are often unreliable and misleading. Therefore, in this paper we propose the utilization of available untransformedsmall intestinal cell lines derived from human and pig tissue of non-tumor origin and describe several available cell models of the gut that offer a functional, close resemblance with the in vivo environment. gut cell models risk assessment toxicology functional food true false false Angleški jezik Angleški jezik Delo ni kategorizirano 2015-07-10 12:23:36 2015-07-10 12:23:36 2022-05-27 03:10:19 2019-07-10 21:34:06 2012 0 0 str. 40-51 no 1 Vol. 1 2012 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 612.39 512252472 512252728 10.3390/foods1010040 2304-8158 URN:SI:UM:DK:PTPYWKCU http://www.mdpi.com/2304-8158/1/1/40 1 https://dk.um.si/Dokument.php?lang=slv&id=74206 Medicinska fakulteta 0 0 0