20.500.12556/DKUM-56121 Simultaneous determination of phthalates, their metabolites, alkylphenols and bisphenol a using GC-MS in urine of men with fertility problems A GC-MS method was successfully applied to measure simultaneously the concentrations of endocrine disrupting compounds (5 dialkyl phthalates, 9 phthalate monoesters, 3 alkylphenols and bisphenol A) in 136 male urine samples. In the present study the method was validated and concentrations of EDCs were determined. The results were compared with results from other studies. Correlations between endocrine disrupting compounds and also correlations of endocrine disrupting compounds with two semen quality parameters are presented and evaluated. Significant positive correlations were found between almost all the endocrine disrupting compounds. The parameter sum of DEHP (SUM DEHP) was positively correlated to all the endocrine disrupting compounds but negatively to two semen quality parameters. Negative correlations between the endocrine disrupting compounds and the semen quality parameters could indicate that endocrine disrupting compounds could cause reproductive problems by decreasing the semen count and quality. This research will have helped to evaluate human exposure to endocrine disrupting compounds. S plinsko kromatografijo in masno spektrometrijo smo simultano določali koncentracije endokrinih motilcev (5 dialkil ftalatov, 9 monoalkil ftalatov, 3 alkilfenole in bisfenol A) v 136 vzorcih moških urinov. Rezultate smo primerjali z ostalimi študijami. Ovrednotili smo korelacije med endokrinimi motilci in korelacije med endokrinimi motilci ter parametri semena. Signifikantne pozitivne korelacije obstajajo med skoraj vsemi endokrinimi motilci. Parameter vsote DEHP (SUM DEHP) pozitivno korelira z vsemi endokrinimi motilci in negativno s paramateri kvalitete semena. Negativne korelacije med endokrinimi motilci ter parametri kvalitete semena nakazujejo, da lahko povzročajo probleme s plodnostjo z zmanjšanjem koncentracije in gibljivosti semena. Raziskava bo pripomogla k ovrednotenju izpostavljenosti ljudi vplivom endokrinih motilcev. endocrine disrupting compounds fertility fertility phthalates bisphenol A alkylphenols human urine analizna kemija endokrini motilci ftalati urin plinska kromatografija kemijska analiza true false true Angleški jezik Slovenski jezik Znanstveno delo 2015-12-21 16:34:34 2015-12-21 16:34:34 2022-06-11 03:08:13 2022-03-30 03:08:44 2014 0 0 str. 110-120 št. 1 Letn. 61 2014 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1318-0207 543.21:663.2 14086149 17710102 1318-0207 URN:SI:UM:DK:GTKMNUGH Acta_Chimica_Slovenica_2014_Kranvogl_et_al._Simultaneous_determination_of_phthalates,_their_metabolites,_alkylphenols_and_bisphenol_A_us.pdf Acta_Chimica_Slovenica_2014_Kranvogl_et_al._Simultaneous_determination_of_phthalates,_their_metabolites,_alkylphenols_and_bisphenol_A_us.pdf 1 984157FBDFF9F93D5BE941D0A9C444D4 7adddc804152373404bc72db7786498050529f3442ad07eaeed383314d53e215 8fa29b46-7c0e-11eb-bb7a-00155d0001ca https://dk.um.si/Dokument.php?lang=slv&id=116023 http://acta-arhiv.chem-soc.si/61/61-1-110.pdf 1 https://dk.um.si/Dokument.php?lang=slv&id=84254 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0