20.500.12556/DKUM-60187 Disinhibition-induced transitions between absence and tonic-clonic epileptic seizures Electrophysiological experiments have long revealed the existence of two-way transitions between absence and tonic-clonic epileptic seizures in the cerebral cortex. Based on a modified spatially-extended Taylor & Baier neural field model, we here propose a computational framework to mathematically describe the transition dynamics between these epileptic seizures. We first demonstrate the existence of various transition types that are induced by disinhibitory functions between two inhibitory variables in an isolated Taylor & Baier model. Moreover, we show that these disinhibition-induced transitions can lead to stable tonic-clonic oscillations as well as periodic spike with slow-wave discharges, which are the hallmark of absence seizures. We also observe fascinating dynamical states, such as periodic 2-spike with slow-wave discharges, tonic death, bursting oscillations, as well as saturated firing. Most importantly, we identify paths that represent physiologically plausible transitions between absence and tonic-clonic seizures in the modified spatially-extended Taylor & Baier model. epilepsy neuronal dynamics synchronization biophysics epilepsija nevronska dinamika sinhronizacija biofizika true true true Angleški jezik Slovenski jezik Članek v reviji 2016-06-09 03:16:04 2017-06-23 10:20:53 2024-05-28 13:05:15 2019-07-11 11:38:12 2015 0 0 str. 1-12 Letn. 5 2015 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 2045-2322 53 18727432 21556488 10.1038/srep12618 2045-2322 URN:SI:UM:DK:CZDGZXTK Scientific_Reports_2015_Fan,_Wang,_Perc_Disinhibition-induced_transitions_between_absence_and_tonic-clonic_epileptic_seizures.pdf Scientific_Reports_2015_Fan,_Wang,_Perc_Disinhibition-induced_transitions_between_absence_and_tonic-clonic_epileptic_seizures.pdf 1 C0062E26E27D4D5B837629BEFEA91D12 e11661e164cda76db2a44abd496ae2f17a0d62c21d037be2ece124efad6b2f8a 49bbcd4e-7c0e-11eb-bb7a-00155d0001ca https://dk.um.si/Dokument.php?lang=slv&id=113002 http://www.nature.com/articles/srep12618 1 https://dk.um.si/Dokument.php?lang=slv&id=94002 Fakulteta za naravoslovje in matematiko 0 0 0