20.500.12556/DKUM-64077 OPTIMIZACIJA REGENERACIJE CIKLOHEKSANA NA REKTIFIKACIJSKI KOLONI OPTIMIZATION OF CYCLOHEXANE REGENERATION BY RECTIFICATION COLUMN Pri sintezi zdravila se kot povratno topilo uporablja cikloheksan. Sestava cikloheksana iz procesa, namenjenega za regeneracijo, je cca 80% cikloheksana, 19% THF, ostanejo še metanol, toluen in aceton. Pri prvi stopnji regeneracije povratnega cikloheksana dobimo 1000L predtoka in cca 1500-2000L regeneriranega povratnega cikloheksana. Sestava: predtok: cikloheksan, THF, metanol, aceton. (45,15% cikloheksan, 53,07% THF, 0,89% metanol, 0,89% aceton) regeneriran povratni cikloheksan: ( 99% cikloheksana, ostalo THF in nekaj malega toluena) Cilj načrtovanih raziskav je bila eksperimentalna določitev procesnih parametrov, s katerimi bi iz predtoka s pomočjo rektifikacije pridobili še preostali cikloheksan. Topilo bi vračali nazaj v sintezo zdravila kot povratni cikloheksan skupaj s povratnim cikloheksanom iz prve stopnje regeneracije. V sklopu diplomskega dela smo podrobno raziskali sledeče segmente: • Določili smo procesne parametre šaržne rektifikacije predtoka. • Določili smo procesne parametre kontinuirne rektifikacije predtoka. • Na podlagi rezultatov obeh rektifikacij smo preučili možnost za celotno regeneracijo povratnega cikloheksana s pomočjo kontinuirne rektifikacije. In the synthesis of medicines cyclohexane is used as a solvent. The composition of the cyclohexane outflow from the process intended for the regeneration is about 80% cyclohexane, 19% THF, remaining components of methanol, toluene and acetone. In the first regeneration stage of cyclohexane outflow, 1000L of foward flow and 1500-2000L regenerated backflow is obtained. Composition: Forward flow : cyclohexane, THF, methanol, acetone. (45.15% cyclohexane, 53.07% THF, 0.89% methanol, 0.89% acetone) Regenerated backflow: (99% cyclohexane, rest THF and toluene) The objective of the research was experimental determination of process parameters in order to separate the remaining cycloheksane from the foward flow by rectification. The cycloheksane obtained in this separation stage would be used together with the regenerated backflow from the first stage in the synthesis of medicines again. In the frame of diploma thesis we have examined in detail the following segments : • We have defined the process parameters of the batch rectification, • We have defined the process parameters of continuous flow rectification, • Based on the results of both rectification models we examined the possibility of regenerating the entire backflow cyclohexane through continuous rectification. regeneracija rektifikacija cikloheksan regeneration rectification cycloheksane true true false [D. Sakulac] Slovenski jezik Angleški jezik Diplomsko delo/naloga 2016-09-21 19:27:07 2016-10-17 11:04:33 2022-07-04 03:06:45 2019-07-11 13:49:39 2016 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 66.048.3.069.82:66.097.38(043.2) 20332822 URN:SI:UM:DK:T7ZKEVYD VS_Sakulac_Dejan_2016.pdf VS_Sakulac_Dejan_2016.pdf 1 B636B8FD54F8F0D92D9F4EB22D57FF70 7f9a18d636496af8693d298eb61df390468e0ed5ab335264fc138af5f79de0ce c1508d5f-7c0d-11eb-bb7a-00155d0001ca https://dk.um.si/Dokument.php?lang=slv&id=107322 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0