20.500.12556/DKUM-65510 Klinična uporabnost biokemijskih označevalcev in testa agregacije trombocitov pri ishemični možganski kapi The clinical usefulness of biochemical markers and platelet aggregation test in ischemic stroke Visoki nivoji VWF so bili napovedniki tako teže možganske kapi kot tudi slabega kliničnega izhoda, ne pa podvrste IMK. VWF bi lahko služil kot prognostični napovednik kliničnega izhoda pri IMK. Nivoji DD, FG in HC niso bili povezani s podvrsto IMK, ne s težo možganske kapi in ne s kliničnim izhodom, zato DD, FG in HC nimajo pomembne diagnostične vrednosti za določeno vrsto IMK ali prognostične vrednosti za klinični izhod po IMK. Visoki nivoji NT-proBNP so bili povezani s kardioembolično IMK ter s težo možganske kapi, ne pa tudi s slabim kliničnim izhodom, zato bi lahko NT-proBNP služil kot diagnostični napovednik za kardioembolično IMK. Merjenje AT je koreliralo z jemanjem aspirina, kar pa ni imelo kliničnega pomena; kljub nizki AT so bolniki utrpeli IMK. Nivoji AT niso bili napovedniki podvrste IMK, teže kapi ali slabega kliničnega izhoda. Z multivariatno regresijsko analizo s posplošenim linearnim modelom smo ugotovili, da so med BKO in AT edini pomembni napovedniki: 1. kardioembolične IMK: NT-proBNP; 2. za težo kapi, ocenjeno z NIHSS: NT-proBNP in VWF:Ag; 3. za klinični izhod, ocenjen z MRL: VWF:Ag. High levels of VWF were predictors of both stroke severity as well as poor clinical outcome, but not for stroke subtype. Therefore VWF could serve as a prognostic factor of clinical outcome in IS. DD, FG and HC levels were not associated with stroke subtype, stroke severity and with clinical outcome; therefore DD, FG and HC have no important diagnostic roles for particular stroke subtypes or prognostic values for clinical outcomes after IS. High levels of NT-proBNP were associated with cardioembolic IS and stroke severity, but not with poor clinical outcome, therefore NT-proBNP can be used as a diagnostic predictor for cardioembolic IS. Measurement of PA correlated with the intake of aspirin prior to stroke, which was not clinically significant; despite low PA patients suffered IS. PA levels were not predictors of particular stroke subtype, severity of stroke or unfavourable clinical outcome. Multivariate regression analysis using generalized linear model showed that the only significant independent predictors among biochemical markers and PA were: 1. for cardioembolic stroke was: NT-proBNP; 2. for stroke severity assessed by NIHSS: NT-proBNP and VWF:Ag; 3. for clinical outcome assessed by MRS: VWF:Ag. akutna ishemična možganska kap TOAST klasifikacija biokemijski označevalci agregacija trombocitov NIHSS MRL acute ischemic stroke TOAST classification biochemical markers platelet aggregation NIHSS MRS true true false Slovenski jezik Angleški jezik Doktorsko delo/naloga 2017-04-17 09:29:18 2017-08-21 11:34:09 2022-07-08 03:08:42 2019-07-11 15:20:37 2017 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 6069055 URN:SI:UM:DK:5NQRICWG DOK_Menih_Marija_2017.pdf DOK_Menih_Marija_2017.pdf 1 3CDDA194BED5EAECB10CD727CBC0F99B c5b7148e68a4f56205f70c8b2d1e3b6a2d52f8d20e4b77d3f57d41ecb0e87a2e 6b0cf6cd-7c0e-11eb-bb7a-00155d0001ca https://dk.um.si/Dokument.php?lang=slv&id=114202 Medicinska fakulteta 0 0 0