20.500.12556/DKUM-65612 Prognostic significance of uPA/PAI-1 level, HER2 status, and traditional histologic factors for survival in node-negative breast cancer patients Background: The association of HER2 status with urokinase plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1) levels raises the question whether uPA/PAI-1 level carries additional clinically relevant prognostic information independently from HER2 status. The aim of our study was to compare the prognostic value of uPA/PAI-1 level, HER2 status, and traditional prognostic factors for survival in node-negative breast cancer patients. Patients and methods: A retrospective analysis of 858 node-negative breast cancer patients treated in Maribor University Clinical Center, Slovenia, in the years 2000-2009 was performed. Data were obtained from patient medical records. The median follow-up time was 100 months. Univariate and multivariate analyses of disease-free (DFS) and overall survival (OS) were performed using the Cox regression and the Cox proportional hazards model. Results: In univariate analysis, age, tumor size, grade, lymphovascular invasion, HER2 status and UPA/PAI-1 level were associated with DFS, and age, tumor size, grade, and uPA/PAI-1 level were associated with OS. In the multivariate model, the most important determinants of DFS were age, estrogen receptor status and uPA/PAI-1 level, and the most important factors for OS were patient age and tumor grade. The HR for death from any cause in the multivariate model was 1.98 (95% CI 0.83-4.76) for patients with high uPA and/or PAI-1 compared to patients with both values low. Conclusions: uPA/PAI-1 level clearly carries an independent prognostic value regardless of HER2 status in node-negative breast cancer and could be used in addition to HER2 and other markers to guide clinical decisions in this setting. node-negative breast cancer adjuvant systemic treatment survival uPA/PAI-1 HER2 status dojka rak (medicina) adjuvantno sistemsko zdravljenje urokinazni aktivator plazminogena plazminogen aktivator inhibitor 1 HER2 status prognoza true false true Angleški jezik Slovenski jezik Znanstveno delo 2017-05-10 11:07:24 2017-05-10 11:08:09 2022-07-08 03:09:18 2019-07-11 15:24:16 2017 0 0 str. 65-73 št. 1 Letn. 51 2017 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1581-3207 618.19-006 784507 5717567 10.1515/raon-2016-0024 1581-3207 URN:SI:UM:DK:3AHMOAMK Radiology_and_Oncology_2017_Dovnik,_Takac_Prognostic_significance_of_uPAPAI-1_level,_HER2_status,_and_traditional_histologic_factors_for.pdf Radiology_and_Oncology_2017_Dovnik,_Takac_Prognostic_significance_of_uPAPAI-1_level,_HER2_status,_and_traditional_histologic_factors_for.pdf 1 1140BBE72E4FAF57632838893A39663C 211d7b7ab679cc3f7491e9ce268647c4fa56bfeadf3d3dc638b5b3f4fae6b06c 1a9dd6f3-7c0e-11eb-bb7a-00155d0001ca https://dk.um.si/Dokument.php?lang=slv&id=111084 http://www.degruyter.com/view/j/raon.2017.51.issue-1/raon-2016-0024/raon-2016-0024.xml 1 https://dk.um.si/Dokument.php?lang=slv&id=111083 Medicinska fakulteta 0 0 0