20.500.12556/DKUM-66188 Single nucleotide polymorphisms as prognostic and predictive factors of adjuvant chemotherapy in colorectal cancer of stages I and II Colorectal cancer (CRC) is a highly heterogeneous disease regarding the stage at time of diagnosis and there is special attention regarding adjuvant chemotherapy in unselected patients with stage I and stage II. The clinicohistologically based TNM staging system with emphasis on histological evaluation of primary tumor and resected regional lymph nodes remains the standard of staging, but it has restricted sensitivity resulting in false downward stage migration. Molecular characteristics might predispose tumors to a worse prognosis and identification of those enables identifying patients with high risk of disease recurrence. Suitable predictive markers also enable choosing the most appropriate therapy. The current challenge facing adjuvant chemotherapy in stages I and II CRC is choosing patients with the highest risk of disease recurrence who are going to derive most benefit without facing unnecessary adverse effects. Single nucleotide polymorphisms (SNPs) are one of the potential molecular markers that might help us identify patients with unfavorable prognostic factors regarding disease initiation and recurrence and could determine selection of an appropriate chemotherapy regimen in the adjuvant and metastatic setting. In this paper, we discuss SNPs of genes involved in the multistep processes of cancerogenesis, metastasis, and the metabolism of chemotherapy that might prove clinically significant. single nucleotide polymorphism colorectal cancer adjuvant chemotherapy enonukleotidni polimorfizem kolorektalni rak adjuvantna kemoterapija true false true Angleški jezik Slovenski jezik Znanstveno delo 2017-06-14 11:11:23 2017-06-14 11:12:18 2022-07-10 03:06:46 2021-05-16 03:19:19 2016 0 0 str. 1-10 Letn. 2016 2016 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1687-630X 616.3-006 4614207 512572984 10.1155/2016/2139489 1687-630X URN:SI:UM:DK:AOSGNBEX Gastroenterology_Research_and_Practice_2016_Horvat_et_al._Single_Nucleotide_Polymorphisms_as_Prognostic_and_Predictive_Factors_of_Adjuva.pdf Gastroenterology_Research_and_Practice_2016_Horvat_et_al._Single_Nucleotide_Polymorphisms_as_Prognostic_and_Predictive_Factors_of_Adjuva.pdf 1 EC28553651F5E911EF43A28068C1D4C2 feed2f1f15d0581b0e3364795046c84cabc6076bf1e1101613fc9c034941eef4 3dc5568a-7c0e-11eb-bb7a-00155d0001ca https://dk.um.si/Dokument.php?lang=slv&id=112504 http://www.hindawi.com/journals/grp/2016/2139489/ 1 https://dk.um.si/Dokument.php?lang=slv&id=112503 Medicinska fakulteta 0 0 0