20.500.12556/DKUM-66223 L-arginine intake effect on adenin nucleotide metabolism in rat parenchymal and reproductive tissues L-arginine is conditionally essential amino acid, required for normal cell growth, protein synthesis, ammonia detoxification, tissue growth and general performance, proposed in the treatment of men sterility and prevention of male impotence. The aim of the present paper was to estimate the activity of the enzymes of adenine nucleotide metabolismČ 5' -nucleotidase ( 5'-NU), adenosine deaminase (ADA), AMP deaminase, and xanthine oxidase (XO), during dietary intake of L-arginine for a period of four weeks of male Wistar rats. Adenosine concentration in tissues is maintained by the relative activities of the adenosine-producing enzyme, 5' -NU and the adenosine-degrading enzyme-ADA adenosine deaminase. Dietary L-arginine intake directed adenine nucleotide metabolism in liver, kidney, and testis tissue toward the activation of adenosine production, by increased 5' -NU activity and decreased ADA activity. Stimulation of adenosine accumulation could be of importance in mediating arginine antiatherosclerotic, vasoactive, immunomodulatory, and antioxidant effects. Assuming that the XO activity reflects the rate of purine catabolism in the cell, while the activity of AMP deaminase is of importance in ATP regeneration, reduced activity of XO, together with the increased AMP-deaminase activity, may suggest that adenine nucleotides are presumably directed to the ATP regenerating process during dietary L-arginine intake. biochemistry biokemija true false true Angleški jezik Slovenski jezik Znanstveno delo 2017-06-15 10:30:08 2017-06-15 10:31:17 2022-07-10 03:06:59 2021-05-15 03:34:32 2012 0 0 str. 1-4 Letn. 2012 2012 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1537-744X 577 2607642 3355948 10.1100/2012/208239 1537-744X URN:SI:UM:DK:TUR5EPGM The_Scientific_World_Journal_2012_Kocic_et_al._L-Arginine_Intake_Effect_on_Adenine_Nucleotide_Metabolism_in_Rat_Parenchymal_and_Reproduc.pdf The_Scientific_World_Journal_2012_Kocic_et_al._L-Arginine_Intake_Effect_on_Adenine_Nucleotide_Metabolism_in_Rat_Parenchymal_and_Reproduc.pdf 1 5C89A1EBD310A88C6FFE706E7145EFFC 01dee0bd382503c232ed61693539741ecc9f98dc3ffa53757635c86789eb96dd 3ff1f4a0-7c0e-11eb-bb7a-00155d0001ca https://dk.um.si/Dokument.php?lang=slv&id=112592 http://www.hindawi.com/journals/tswj/2012/208239/ 1 https://dk.um.si/Dokument.php?lang=slv&id=112591 Medicinska fakulteta 0 0 0