20.500.12556/DKUM-66226 The study of release of chlorhexidine from preparations with modified thermosensitive poly-n-isopropylacrylamide microspheres The aim of this study was to investigate and compare the release rates of chlorhexidine (CX) base entrapped in the polymeric beads of modified poly-N-isopropylacrylamides (pNIPAMs) at temperatures below and over the volume phase transition temperature (VPTT) of synthesized polymers: pNIPAM-A with terminal anionic groups resulting from potassium persulfate initiator, pNIPAM-B with cationic amidine terminal groups, and pNIPAM-C comprising anionic terminals, but with increased hydrophobicity maintained by the N-tert-butyl functional groups. The preparations, assessed in vitro below the VPTT, release an initial burst of CX at different time periods between 120 and 240 min, followed by a period of 24 h, when the rate of release remains approximately constant, approaching the zero-order kinetics; the release rates for the polymers beads are as follows: pNIPAM-C>pNIPAM-B>pNIPAM-A. The pattern of release rates at temperature over the VPTT is as follows: pNIPAM-C>pNIPAM-A>pNIPAM-B. In the presence of pNIPAM-C, the duration between the start of the release and the attained minimal inhibitory concentration (MIC) for most of the microbes, in conditions over the VPTT, increased from 60 to 90 min. The release prolongation could be ascribed to some interactions between the practically insoluble CX particle and the hydrophobic functional groups of the polymer. chlorhexidine synthesized polymers thermosensitivity klorheksidin sintetizirani polimeri termoobčutljivost true false true Angleški jezik Slovenski jezik Znanstveno delo 2017-06-15 11:16:08 2017-06-15 11:16:09 2022-07-10 03:07:00 2021-05-15 03:35:55 2012 0 0 str. 1-8 Letn. 2012 2012 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1537-744X 2607642 10.1100/2012/243707 1537-744X URN:SI:UM:DK:VKKOUSGF The_Scientific_World_Journal_2012_Musial_et_al._The_Study_of_Release_of_Chlorhexidine_from_Preparations_with_Modified_Thermosensitive_Po.pdf The_Scientific_World_Journal_2012_Musial_et_al._The_Study_of_Release_of_Chlorhexidine_from_Preparations_with_Modified_Thermosensitive_Po.pdf 1 B30042996337AC161F348959DD9F4E00 8052cd378ad378189614a913f142210181b9b24a7a26f413f64b53bc74121014 401efb78-7c0e-11eb-bb7a-00155d0001ca https://dk.um.si/Dokument.php?lang=slv&id=112597 http://www.hindawi.com/journals/tswj/2012/243707/ 1 https://dk.um.si/Dokument.php?lang=slv&id=112598 Fakulteta za strojništvo 0 0 0