20.500.12556/DKUM-66274 Family history as a predictor for disease risk in healthy individuals a cross-sectional study in Slovenia Background Family history can be used as a genetic risk predictor for common non-communicable diseases. The aim of this study was to determine the prevalence of healthy individuals at risk of developing these diseases, based on their self-reported family history.Methods and Findings This was a cross-sectional observational study. Data were collected in the three largest occupational practices in primary health care centres in Slovenia, a Central European country. The study population consisted of consecutive individuals who came to occupational practices for their regular preventive check-up from November 2010 to June 2012. We included 1,696 individuals. Data were collected by a self-developed questionnaire. The main outcome was the number of participants at a moderate or high risk for the development of cardiovascular diseases, diabetes, and cancer.The final sample consisted of 1,340 respondents. Moderate or high risk for the development of cardiovascular diseases was present in 280 (20.9%) participants, for the development of diabetes in 154 (11.5%) participants and for cancer in 163 (12.1%) participants. Conclusions In this study, we found a significant proportion of healthy individuals with an increased genetic risk for common non-communicable diseases; consequently further genetic and clinical evaluation and preventive measures should be offered. family history predictor for disease risk sectional study in Slovenia družinska zgodovina napovedni dejavnik tveganja sekcijska študija v Sloveniji true false true Angleški jezik Slovenski jezik Znanstveno delo 2017-06-19 09:19:37 2017-06-19 09:20:29 2022-07-11 03:05:59 2019-07-11 11:36:40 2013 0 0 str. 1-5 št. 11 Letn. 8 Nov. 2013 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1932-6203 577 2005896 30946009 10.1371/journal.pone.0080333 1932-6203 URN:SI:UM:DK:IBD67CLJ PLoS_ONE_2013_Klemenc-Ketis,_Peterlin_Family_History_as_a_Predictor_for_Disease_Risk_in_Healthy_Individuals_A_Cross-Sectional_Study_in_S.PDF PLoS_ONE_2013_Klemenc-Ketis,_Peterlin_Family_History_as_a_Predictor_for_Disease_Risk_in_Healthy_Individuals_A_Cross-Sectional_Study_in_S.PDF 1 1089004237BB5023F9B865F628B2DEA0 6d12db49655cc5858abe4de4700a92579d665ad03f848a8791ceb5cb84e4a312 427a7243-7c0e-11eb-bb7a-00155d0001ca https://dk.um.si/Dokument.php?lang=slv&id=112728 http://dx.plos.org/10.1371/journal.pone.0080333 1 https://dk.um.si/Dokument.php?lang=slv&id=112727 Medicinska fakulteta 0 0 0