20.500.12556/DKUM-66354 Polyphenols: extraction methods, antioxidative action, bioavailability and anticarcinogenic effects Being secondary plant metabolites, polyphenols represent a large and diverse group of substances abundantly present in a majority of fruits, herbs and vegetables. The current contribution is focused on their bioavailability, antioxidative and anticarcinogenic properties. An overview of extraction methods is also given, with supercritical fluid extraction highlighted as a promising eco-friendly alternative providing exceptional separation and protection from degradation of unstable polyphenols. The protective role of polyphenols against reactive oxygen and nitrogen species, UV light, plant pathogens, parasites and predators results in several beneficial biological activities giving rise to prophylaxis or possibly even to a cure for several prevailing human diseases, especially various cancer types. Omnipresence, specificity of the response and the absence of or low toxicity are crucial advantages of polyphenols as anticancer agents. The main problem represents their low bioavailability and rapid metabolism. One of the promising solutions lies in nanoformulation of polyphenols that prevents their degradation and thus enables significantly higher concentrations to reach the target cells. Another, more practiced, solution is the use of mixtures of various polyphenols that bring synergistic effects, resulting in lowering of the required therapeutic dose and in multitargeted action. The combination of polyphenols with existing drugs and therapies also shows promising results and significantly reduces their toxicity. polyphenols extraction antioxidants bioavailability synergistic effects polifenoli ekstrakcija antioksidanti biološka uporabnost sinergijski efekti true false true Angleški jezik Slovenski jezik Znanstveno delo 2017-06-22 08:45:33 2017-06-22 08:46:42 2022-07-11 03:06:27 2019-07-11 15:44:35 2016 0 0 str. 1-38 št. 7 Letn. 21 2016 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1420-3049 54 18462981 19672598 10.3390/molecules21070901 1420-3049 URN:SI:UM:DK:3H0NTTTR Molecules_2016_Brglez_Mojzer_et_al._Polyphenols_Extraction_Methods,_Antioxidative_Action,_Bioavailability_and_Anticarcinogenic_Effects.pdf Molecules_2016_Brglez_Mojzer_et_al._Polyphenols_Extraction_Methods,_Antioxidative_Action,_Bioavailability_and_Anticarcinogenic_Effects.pdf 1 CB633C5D19901AB89C27279D6C246BCC d560a82d7aa8f5b213b116ab6488c0028a13f6ff87d0bb4c9f7796311e0c9581 47635c4d-7c0e-11eb-bb7a-00155d0001ca https://dk.um.si/Dokument.php?lang=slv&id=112909 http://www.mdpi.com/1420-3049/21/7/901 1 https://dk.um.si/Dokument.php?lang=slv&id=112908 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0