20.500.12556/DKUM-66406 Novel chitosan/diclofenac coatings on medical grade stainless steel for hip replacement applications Corrosion resistance, biocompatibility, improved osteointegration, as well the prevention of inflammation and pain are the most desired characteristics of hip replacement implants. In this study we introduce a novel multi-layered coating on AISI 316LVM stainless steel that shows promise with regard to all mentioned characteristics. The coating is prepared from alternating layers of the biocompatible polysaccharide chitosan and the non-steroid anti-inflammatory drug (NSAID), diclofenac. Electrochemical methods were employed to characterize the corrosion behavior of coated and uncoated samples in physiological solution. It is shown that these coatings improve corrosion resistance. It was also found that these coatings release the incorporated drug in controlled, multi-mechanism manner. Adding additional layers on top of the as-prepared samples, has potential for further tailoring of the release profile and increasing the drug dose. Biocompatibility was proven on human-derived osteoblasts in several experiments. Only viable cells were found on the sample surface after incubation of the samples with the same cell line. This novel coating could prove important for prolongation of the application potential of steel-based hip replacements, which are these days often replaced by more expensive ceramic or other metal alloys. corrosion corrosion resistance chitosan biocompatibility biomaterials biomedical materials coatings stainless steel korozija hitozan korozijska odpornost biokompatibilnost biomedicinski materiali premazi nerjaveče jeklo true false true Angleški jezik Slovenski jezik Znanstveno delo 2017-06-23 12:10:09 2017-06-23 12:11:09 2022-07-11 03:06:46 2019-07-11 15:46:22 2016 0 0 str. 1-17 Letn. 6 Published online:24 May 2016 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 2045-2322 57.089:669.14.018.8 18727432 19591446 10.1038/srep26653 2045-2322 URN:SI:UM:DK:GRAMBIYY Scientific_Reports_2016_Finsgar_et_al._Novel_chitosandiclofenac_coatings_on_medical_grade_stainless_steel_for_hip_replacement_applicatio.pdf Scientific_Reports_2016_Finsgar_et_al._Novel_chitosandiclofenac_coatings_on_medical_grade_stainless_steel_for_hip_replacement_applicatio.pdf 1 2333A1976E1086E909A8221F20E4011D 45f2615583007bc80b915679cd18b2354b042daed81f3d4bbdf10fc6abea63ec 4ad2ff57-7c0e-11eb-bb7a-00155d0001ca https://dk.um.si/Dokument.php?lang=slv&id=113033 http://www.nature.com/articles/srep26653 1 https://dk.um.si/Dokument.php?lang=slv&id=113032 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0