20.500.12556/DKUM-66409 Regulation of irregular neuronal firing by autaptic transmission The importance of self-feedback autaptic transmission in modulating spike-time irregularity is still poorly understood. By using a biophysical model that incorporates autaptic coupling, we here show that self-innervation of neurons participates in the modulation of irregular neuronal firing, primarily by regulating the occurrence frequency of burst firing. In particular, we find that both excitatory and electrical autapses increase the occurrence of burst firing, thus reducing neuronal firing regularity. In contrast, inhibitory autapses suppress burst firing and therefore tend to improve the regularity of neuronal firing. Importantly, we show that these findings are independent of the firing properties of individual neurons, and as such can be observed for neurons operating in different modes. Our results provide an insightful mechanistic understanding of how different types of autapses shape irregular firing at the single-neuron level, and they highlight the functional importance of autaptic self-innervation in taming and modulating neurodynamics. neuronal dynamics autapse regulation excitation nevronska dinamika avtapsa regulacija eksitacije true true true Angleški jezik Slovenski jezik Članek v reviji 2017-06-23 12:29:43 2017-06-23 12:30:33 2024-05-28 10:41:29 2019-07-11 15:46:28 2016 0 0 str. 1-14 Letn. 6 2016 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 2045-2322 53 18727432 22210568 10.1038/srep26096 2045-2322 URN:SI:UM:DK:8NOX4XBV Scientific_Reports_2016_Guo_et_al._Regulation_of_Irregular_Neuronal_Firing_by_Autaptic_Transmission.pdf Scientific_Reports_2016_Guo_et_al._Regulation_of_Irregular_Neuronal_Firing_by_Autaptic_Transmission.pdf 1 4CB28F503AABD37E79B6A3282E85FF3C ea4ef311584d9a4d0a1729e15c3cfb6ff424ecbdecfea31b9523ecbd299c5ef9 4b0ef60a-7c0e-11eb-bb7a-00155d0001ca https://dk.um.si/Dokument.php?lang=slv&id=113040 http://www.nature.com/articles/srep26096 1 https://dk.um.si/Dokument.php?lang=slv&id=113039 Fakulteta za naravoslovje in matematiko 0 0 0