20.500.12556/DKUM-66785 Haploinsufficiency for steroidogenic factor 1 affects maternal behavior in mice Steroidogenic factor 1 (SF-1), officially designated NR5A1, is essential for gonadal and adrenal development and for the normal structure of the ventromedial hypothalamus (VMH), as demonstrated by SF-1 knockout mice (SF-1 KO), but much less is known about the possible effects of haploinsufficiency of the SF-1 gene. In the present study, maternal behavior in SF-1 KO heterozygous mice was evaluated. Behavioral tests revealed that SF-1 KO heterozygous females have impaired maternal behavior. In comparison to wild-type (WT) females, SF-1 KO heterozygous females retrieved significantly fewer pups into their nests, latency to retrieve and crouch over the pups was longer, and their nests were lower quality. As suggested by previous studies full dosage of SF-1 gene is needed for appropriate stress response and expression of brain-derived neurotrophic factor (BDNF) in the brain, and this might present a mechanism through which maternal behavior in SF-1 KO heterozygous females is impaired. mice stress steroidogenic factor 1 maternal behavior miši stres steroidogenski faktor 1 materinsko vedenje true false true Angleški jezik Slovenski jezik Znanstveno delo 2017-07-10 12:26:19 2017-07-10 12:27:56 2022-08-01 13:10:05 2019-07-11 15:58:50 2016 0 0 str. 1-5 Letn. 10 2016 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1662-5153 612 20809480 4164474 10.3389/fnbeh.2016.00131 1662-5153 URN:SI:UM:DK:3R05HJL9 Frontiers_in_behavioral_neuroscience_2016_Spanic,_Grgurevic,_Majdic_Haploinsufficiency_for_Steroidogenic_Factor_1_Affects_Maternal_Behav.pdf Frontiers_in_behavioral_neuroscience_2016_Spanic,_Grgurevic,_Majdic_Haploinsufficiency_for_Steroidogenic_Factor_1_Affects_Maternal_Behav.pdf 1 1A86042C9A081A0DE5A1FC4FE6278F78 576cd297193717d022af30bc91272ac80628732ee3f7cdd1d37f4422190c2767 63b1e4a7-7c0e-11eb-bb7a-00155d0001ca 20.500.12556/dkum/b086c2b1-30da-4bab-9198-2aa284a934a5 https://dk.um.si/Dokument.php?lang=slv&id=113958 http://journal.frontiersin.org/article/10.3389/fnbeh.2016.00131/full 1 https://dk.um.si/Dokument.php?lang=slv&id=113957 Medicinska fakulteta 0 0 0