20.500.12556/DKUM-66836 Odpornost proti protimikrobnim zdravilom povzročiteljev zoonoz izoliranih iz živali in živil v Republiki Sloveniji v letih 2008 do 2013 Antimikrobial resistance in zoonotic agents isolated from animals and food in the Republic of Slovenia in the years from 2009 to 2013 V magistrski nalogi smo preverjali, ali sta trenda prodaje protimikrobnih zdravil za zdravljenje živali, namenjenih proizvodnji hrane in mikrobne odpornosti v živalih in živalskem tkivu, povezana. Zbrali in analizirali smo podatke o prometu s protimikrobnimi zdravili in odpornosti mikroorganizmov v Republiki Sloveniji od leta 2008 do leta 2013. V analizo smo vključili dva povzročitelja zoonoz (Salmonella, Campylobacter) in indikatorsko bakterijo (Escherichia coli, nepatogena). Za obdelavo pridobljenih podatkov smo uporabili programa SPSS in Excel. S hi-kvadrat analizo smo pri spremenljivkah mikrobna odpornost (da, ne) in prodaja protimikrobnih zdravil (majhna, srednja, velika) preverili, ali sta spremenljivki povezani. Regresijsko analizo smo izvedli v Excelu. Za protimikrobna zdravila smo izrisali trendne grafikone prodaje protimikrobnih zdravil (%) in mikrobne odpornosti (%) po letih (od 2008 do 2013) in grafikone odvisnosti mikrobne odpornosti (%) od prodaje protimikrobnih zdravil (%). Iz slednjih smo dobili determinacijske koeficiente in jih preračunali v korelacijske koeficiente. Z raziskavo smo pokazali, da se v Republiki Sloveniji, kljub občutnemu zmanjšanju prodaje protimikrobih zdravil v veterini v letih od 2008 do 2013, mikrobna odpornost proti protimikrobnim zdravilom v izolatih živalskih tkiv in fecesa ni zmanjšala, v večini primerov je celo naraščala ali ostajala enaka. Porast števila odpornih mikroorganizmov je verjetno posledica ohranjanja in širjenja odpornosti med mikroorganizmi in teh med živalmi. The objective of this master thesis was to check wether the trend of the sales of the antimicrobial agents for the treatment of food animals is related to the trend of the antimicrobial resistance in the animals and animal tissue. We gathered and analyzed data on the sale of antimicrobials and on the antimicrobial resistance in the Republic of Slovenia from the year 2008 to the year 2013. Two zoonotic agents (Salmonella, Campylobacter) and one indicator bacteria (Escherichia coli, non-pathogenic) were included. To process the acquired data we used SPSS and Excel. The chi-square analysis was used to show if the variables microbial resistance (yes, no) and sales (small, medium, large) are related. The regression analysis was conducted in Excel. Trend graphs (from 2008 to 2013) and dependency graphs of microbial resistance (%) and sales of antimicrobials (%) were performed. From the latter we got the coefficients of determination and converted them into the correlation coefficients. With the research we have found that in the Republic of Slovenia, despite the significant reduction in the sales of antimicrobials drugs in veterinary medicine in the years from 2008 to 2013, microbial resistance to antimicrobials in isolates from animal tissue and faecal matter did not diminish, in most cases it even increased or remained the same. Increase in the number of resistant microorganisms is probably due to the preservation and spread of resistance among microorganisms and those between animals. povzročitelji zoonoz živali živalska tkiva prodaja protimikrobnih zdravil odpornost proti protimikrobnim zdravilom zoonotic agents animals animal tissues sales of antimicrobials antimicrobial resistance true true false Slovenski jezik Angleški jezik Magistrsko delo/naloga 2017-07-12 11:40:27 2017-08-22 09:15:11 2022-08-01 13:13:37 2019-07-11 16:00:25 2017 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 URN:SI:UM:DK:N28J2LD2 MAG_Grabnar_Dobnikar_Neza_2017.pdf MAG_Grabnar_Dobnikar_Neza_2017.pdf 1 DEF75CCC597990A2A05F781734BE0325 a9d75b9fee8fa8ed8a472da9c285879e9faccd10a4a488cbd597a06273063074 80844119-7c0e-11eb-bb7a-00155d0001ca 20.500.12556/dkum/4e4b7064-cc47-4e03-9bb0-18457b2f9f34 https://dk.um.si/Dokument.php?lang=slv&id=115153 Fakulteta za kmetijstvo in biosistemske vede 0 0 0