20.500.12556/DKUM-67140 Vesiculation of biological membrane driven by curvature induced frustrations in membrane orientational ordering Membrane budding often leads to the formation and release of microvesicles. The latter might play an important role in long distance cell-to-cell communication, owing to their ability to move with body fluids. Several mechanisms exist which might trigger the pinching off of globular buds from the parent membrane (vesiculation). In this paper, we consider the theoretical impacts of topological defects (frustrations) on this process in the membranes that exhibit global in-plane orientational order. A Landau–de Gennes theoretical approach is used in terms of tensor orientational order parameters. The impact of membrane shapes on position and the number of defects is analyzed. In studied cases, only defects with winding numbers m = ±1/2 appear, where we refer to the number of defects with m = 1/2 as defects, and with m = –1/2 as anti-defects. It is demonstrated that defects are attracted to regions with maximal positive Gaussian curvature, K. On the contrary, anti-defects are attracted to membrane regions exhibiting minimal negative values of K. We show on membrane structures exhibiting spherical topology that the coexistence of regions with K > 0 and K < 0 might trigger formation of defect–anti-defect pairs for strong enough local membrane curvatures. Critical conditions for triggering pairs are determined in several demonstrative cases. Then the additionally appeared anti-defects are assembled at the membrane neck, where K < 0. Consequent strong local fluctuations of membrane constituent anisotropic molecules might trigger membrane fission neck rupture, enabling a membrane fission process and the release of membrane daughter microvesicles (ie, vesiculation). structural transitions topological defects membrane microvesicles membrane curvature membrane fission vesiculation strukturni prehodi topološke napake mikrovezikli membran ukrivljenost membrane cepitev membrane vezikulacija true true true S. Seifullin Kazakh Agrotechnical University Angleški jezik Slovenski jezik Znanstveno delo 2017-08-03 11:57:29 2017-08-03 11:58:43 2026-09-04 12:37:05 2019-07-11 16:10:20 2013 0 0 str. 677-687 št. 1 Letn. 8 2013 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2013-02-20 1178-2013 577.352:61 3223828 4516971 10.2147/IJN.S38314 1178-2013 URN:SI:UM:DK:HETDPNP7 International_Journal_of_Nanomedicine_2013_Jesenek_et_al._Vesiculation_of_biological_membrane_driven_by_curvature_induced_frustrations_i.pdf International_Journal_of_Nanomedicine_2013_Jesenek_et_al._Vesiculation_of_biological_membrane_driven_by_curvature_induced_frustrations_i.pdf 1 1EB8EE912EADC21C2FCD37FDCC9EF960 c2caf95a16cceb625e6e3883cfbdeae122ed082cea2c468bee345f236885c52f 7928bef0-7c0e-11eb-bb7a-00155d0001ca 20.500.12556/dkum/086d1dbd-8d33-4036-94f7-020f22665f3a https://dk.um.si/Dokument.php?lang=slv&id=114796 http://www.dovepress.com/vesiculation-of-biological-membrane-driven-by-curvature-induced-frustr-peer-reviewed-article-IJN 1 https://dk.um.si/Dokument.php?lang=slv&id=114795 Fakulteta za naravoslovje in matematiko 0 0 0