20.500.12556/DKUM-67667 Formuliranje farmacevtskih učinkovin s PGSS procesom Formulation of pharmaceutical substances using a PGSS process V diplomskem delu je predstavljeno formuliranje farmacevtskih učinkovin s PGSSTM procesom. Mikronizacijo smo izvedli s pomočjo superkritičnega CO2 in treh različnih aktivnih učinkovin (fenofibrat, nimodipin in O-vanilin) in dveh polimerih nosilcev (Brij S100 in PEG 4000). Vzorce smo pršili skozi šobo premera 1 mm pri 60° naklonu po 1 h homogenizacije. Eksperimente smo izvajali pri štirih različnih tlakih (10 MPa, 15 MPa, 20 MPa in 25 MPa) in pri dveh različnih koncentracijah (2 g učinkovine in 4 g učinkovine na 20 g nosilca). Po končani mikronizaciji smo izračunali izkoristek pršenja in vzorce poslali na analizo velikosti mikro delcev s postopkom CILAS, kjer smo dobili podatke o velikosti srednjega zrna, najmanjših in največjih delcih ter graf njihove porazdelitve. Nato smo vzorce analizirali s pomočjo tekočinske kromatografije z masno spektrometrijo, kjer smo dobili kot rezultat masne spektre in kvantitativne vrednosti učinkovin znotraj vsakega posameznega vzorca, iz katerih smo izračunali dejansko prisotnost učinkovine v vzorcu po PGSSTM procesu. Vzorce smo analizirali tudi z elektronskim mikroskopom (SEM), da smo dobili podatke o morfološki sestavi in formulaciji učinkovine v nosilcu. Formulation of phaurmaceutical substances with PGSSTM process is presented in the thesis. Micronization of three different active substances (Fenofibrate, Nimodipine, O-vaniline) with supercritical CO2 has been investigated. Two different polymers (Brij S100 and PEG 4000) have been used as carriers. Samples have been sprayed through the nozzle of 1 mm diameter at 60 o incline after 1 hour of homogenization. Experiments were carried out at four different pressures (10 MPa, 15 MPa, 20 MPa, 25 MPa) and two different concentraions (2 g or 4 g of active substance per 20 g of carrier). After completed micronization, process efficency has been evaluated and the samples were sent to the size analysis by the CILAS procedure, to obtain data on the size of the middle grain, sizes of the smallest and the largest particles and also the distribution diagrams. Micronized samples were analyzed by liquid chromatography coupled with mass spetrometry, resulting in mass spectra and quantitative evaluation on presence of active substance in samples after PGSSTM process. Two samples were also analyzed by a scanned electron microscope (SEM) to obtain images of a sample by scanning its surface. fenofibrat nimodipin O-vanilin superkritični CO2 mikronizacija Brij S100. Fenofibrate Nimodipine O-Vanilline supercritical CO2 micronization Brij S 100. true true false [U. Filipič] Slovenski jezik Angleški jezik Diplomsko delo/naloga 2017-08-26 18:41:33 2017-09-14 11:02:58 2022-08-01 14:18:12 2019-07-11 16:27:27 2017 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 661.12(043.2) 21040150 URN:SI:UM:DK:ZN6DFWKK VS_Filipic_Uros_2017.pdf VS_Filipic_Uros_2017.pdf 1 6B4992BDD2737CD09B47A037145824FB 83069614b6f132b3a83b9daebcf91a805aa9674f303c47ff28cd5df584b335e6 a6330c6a-7c0e-11eb-bb7a-00155d0001ca 20.500.12556/dkum/169fe02e-df31-442e-a502-7c2816609099 https://dk.um.si/Dokument.php?lang=slv&id=117275 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0