20.500.12556/DKUM-70362 Nanoliposome encapsulation with donkey milk bioactive proteins and its possible application in dermatology and cosmetics Enkapsulacija nanolipozoma bioaktivnim proteinima magarećeg mleka i mogućnost primene u dermatologiji i kozmetologiji Nanoliposomes represent natural or synthetic nanoparticles made of phospholipids, which may spontaneously aggregate in an aqueous medium. Their use in dermatology and for cosmetic purposes may offer facilitated delivery in skin via enhanced opening of the tight junctions between the epithelial cell monolayers. As far as their use in dermatology is concerned, both transdermal and local application may offer successful release profile. Donkey milk may have special therapeutic properties when used in cosmetology for skin treatment. The aim of our study was to establish encapsulation efficacy of nanoliposome loaded with skimmed donkey milk and to explore the efficiency of encapsulation of different skimmed donkey milk concentrations in nanoliposomes. In our experimental study, it was documented that 1%, 2% and 5% solutions of skimmed donkey milk were almost equally effectively encapsulated, more than 80% in 1% solution of nanoliposomes, while 10% solution of skimmed donkey milk was encapsulated more efficiently, with 88.9% in 1% of nanoliposome solution. Encapsulation can lead to greater efficiency by enabling the use of lower administration doses and preventing the corresponding side effects, which may be the result of higher doses. Skimmed donkey milk is a suitable encapsulation solution. Nanolipozomi predstavljaju prirodne ili sintetske nanočestice sačinjene od fosfolipida koje mogu spontano da agregiraju u vodenoj sredini. Njihova upotreba u dermatologiji i u kozmetičke svrhe može omogućiti ubrzanu aplikaciju i prodiranje u kožu jer dolazi do lakšeg otvaranja spojeva između epitelnih ćelija. Kada je u pitanju korišćenje u dermatologiji, i transdermalna i lokalna aplikacija su veoma efikasne. Magareće mleko se pokazalo kao potencijalno veoma korisno kada se koristi u kozmetičke svrhe za tretman kože. Cilj ove studije bio je da se ispita efikasnost enkapsulacije nanolipozoma, koji su tretirani obezmašćenim magarećim mlekom, kao i da se ispita koliki je kapacitet enkapsulacije u uslovima različitih korišćenih koncentracija mleka. U našoj eksperimentalnoj studiji pokazano je da je 1%, 2% i 5% rastvora obezmašćenog magarećeg mleka gotovo jednako efikasno enkapsulirano i to više od 80%, kada se koristila koncentracija od 1% nanolipozoma, dok je 10% rastvora obezmašćenog magarećeg mleka bilo još efikasnije enkapsulirano i to čak 88,9%, kada se koristila koncentracija nanolipozoma od 1%. Enkapsulacija supstanci u nanolipozome je proces koji omogućava korišćenje manjih doza potrebnih supstanci, što dovodi do manje šanse da se pojave štetni efekti u poređenju sa većim dozama. Obezmašćeno magareće mleko je rastvor koji je veoma pogodan za metodu enkapsulacije nanolipozoma. nanoliposomes donkey milk encapsulation efficacy nanolipozomi magareće mleko efikasnost enkapsulacije osličje mleko učinkovitost enkapsulacije true false true Angleški jezik Srbski jezik Znanstveno delo 2018-05-07 10:58:11 2018-05-07 10:59:42 2022-08-01 19:14:26 2019-07-11 18:04:40 2017 0 0 str. 199-204 št. 3 Letn. 34 2017 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 2217-2521 615.454.1:615.324 519332633 512790584 10.1515/afmnai-2017-0021 2217-2521 URN:SI:UM:DK:LW580KM8 Acta_Facultatis_Medicae_Naissensis_2017_Kocic,_Stankovic,_Arsic_Nanoliposome_Encapsulation_with_Donkey_Milk_Bioactive_Proteins_and_Its_P.pdf Acta_Facultatis_Medicae_Naissensis_2017_Kocic,_Stankovic,_Arsic_Nanoliposome_Encapsulation_with_Donkey_Milk_Bioactive_Proteins_and_Its_P.pdf 1 4E8CD72978117037E89E781B94CA07C7 f6c50f567cc7a5f45547bd21e9a6ae603ea45f577dfa25e0f896549915c93b26 ee7faa58-7c0f-11eb-bb7a-00155d0001ca 20.500.12556/dkum/437e4d0c-803c-4551-a1dd-d45bd6ac0c38 https://dk.um.si/Dokument.php?lang=slv&id=124374 https://content.sciendo.com/view/journals/afmnai/34/3/article-p199.xml 1 https://dk.um.si/Dokument.php?lang=slv&id=124373 Medicinska fakulteta 0 0 0