20.500.12556/DKUM-70947 Optimizacija silikatne prevleke NiCu nanodelcev za aplikacije v medicini Optimization of the silicate coating of NiCu nanoparticles for medical applications Pri tej diplomski nalogi smo raziskovali vpliv debeline silikatne prevleke sintetiziranih NiCu nanodelcev na njihovo magnetizacijo in iskali najboljše pogoje za izluževanje silikatne prevleke iz NiCu nanodelcev. Uporabljali smo več različnih metod za karakterizacijo sintetiziranih NiCu nanodelcev. Za določitev sestave nanodelcev smo uporabili rentgensko praškovno difrakcijo (XRD); pri meritvi Curiejeve temperature smo uporabili modificirano termogravimetrično analizo (TGA); velikosti nanodelcev smo določili s pomočjo rentgenske praškovne difrakcije, z dinamičnim sipanjem svetlobe (DLS) in s transmisijsko elektronsko mikroskopijo (TEM); pri določanju prisotnosti silike smo uporabili meritve zeta potenciala, transmisijsko elektronsko mikroskopijo in infrardečo spektroskopijo s Fourierjevo transformacijo (FTIR). Opravili smo tudi magnetne meritve, katere smo izmerili na magnetometru z vibrajočim vzorcem (VSM), in kalorimetrične meritve. Za izluževanja smo uporabili raztopino NaOH, ki je vsebovala 3 % hidrazin. Pri optimizaciji izluževanja smo spreminjali čas izluževanja in koncentracijo NaOH. Uspelo nam je izboljšati pogoje izluževanja iz 1 M NaOH, 24 h, s 3 % hidrazinom, na 0,7 M NaOH, 8 h, s 3 % hidrazinom. Preverili smo tudi izluževanje s 4 % tetrametilamonijevim hidroksidom (TMAH), 4 h, vendar izluževanje ni uspelo. Vpliva debeline silikatne prevleke na magnetizacijo NiCu nanodelcev nismo uspeli določiti, saj se silika ni homogeno razporedila okoli nanodelcev, ampak se je nakopičila na določenih delih vzorca. Sintetizirani NiCu nanodelci niso bili homogeni. Zaradi njihove povprečne Curiejeve temperature, magnetizacije in velikosti so nanodelci primerni za uporabo v magnetni hipertermiji. In this bachelor's thesis, we researched the effects of the thickness of the silicate coating of synthesized NiCu nanoparticles on their magnetization, as well as the optimal conditions for the leaching of the silicate coating from NiCu nanoparticles. We utilized several different methods to determine the chemical properties of the synthesized NiCu nanoparticles. In determining the composition of the nanoparticles, we used X-ray diffraction (XRD); for the measurement of the Curie temperature we used thermogravimetric analysis (TGA); we obtained the size values of the nanoparticles using X-ray diffraction, dynamic light scattering (DLS) and transmission electron microscopy (TEM), while the presence of the silicate coating was investigated using zeta potential, transmission electron microscopy and Fourier-transform infrared spectroscopy (FTIR). We also performed magnetic measurements, for which we used a vibrating-sample magnetometer (VSM), and calorimetric measurements. For the leaching process, we used a NaOH solution, which also contained 3 % hydrazine. During the optimization of the leaching process, we changed the duration of the leaching and concentration of the NaOH. We managed to improve the conditions of the leaching process from 1 M NaOH, 24 h, with 3 % hydrazine, to 0,7 M NaOH, 8 h, with 3 % hydrazine. We also attempted leaching with 4 % tetramethylammonium hydroxide (TMAH), 4 h, but it was unsuccessful. We were unable to determine the effects of the thickness of the silicate coating on the magnetization of synthesized NiCu nanoparticles, as the silica did not homogeneously spread across their surface but accumulated in larger clusters across the entire sample. The synthesized NiCu nanoparticles were found to be heterogenous and suitable for use in magnetic hyperthermia, because of their average Curie temperature, magnetization, and size. NiCu nanodelci izluževanje silikatna prevleka tetrametilamonijev hidroksid (TMAH) NiCu nanoparticles leaching silicate coating tetramethylammonium hydroxide (TMAH) true true false [A. Degen] Slovenski jezik Angleški jezik Diplomsko delo/naloga 2018-06-22 11:01:02 2018-10-04 14:16:18 2022-08-01 20:10:42 2019-07-11 18:25:07 2018 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 620.3:[606:61](043.2) 21963030 URN:SI:UM:DK:1UGZ0G2L UN_Degen_Aljaz_2018.pdf UN_Degen_Aljaz_2018.pdf 1 16EE6608F442560AAE7821C18DC3DC86 f6168906faf12e6655bf6daa05430b20e553bf50c9a8165991b99cb9b8f5abd4 4762b771-7c10-11eb-bb7a-00155d0001ca 20.500.12556/dkum/8a041f3f-14e1-442c-b020-81595de82a2e https://dk.um.si/Dokument.php?lang=slv&id=128978 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0