20.500.12556/DKUM-75859 Potencial kurkumina v klinični uporabi The potential of curcumin in clinical use V magistrskem delu smo predstavili rastlino kurkumo in njeno učinkovino kurkumin. Sama rastlina kurkuma (Curcuma longa) uspeva na Indijskem polotoku in jugovzhodni Aziji ter se že izredno dolgo uporablja v ajurvedski medicini za zdravljenje vnetnih bolezni. Številne moderne študije so pokazale pozitivne učinke kurkumina pri mnogih bolezenskih stanjih, kot so: rak, ulcerozni kolitis, revmatoidni artritis, pankreatitis, osteoartritis in številnih drugih. Največja težava pri uporabi kurkumina za zdravljenje v moderni medicini je njegova slaba biorazpoložljivost, saj so v krvni plazmi zaznali zelo majhne koncentracije kurkumina tudi ob zaužitju večjih doz. V sami nalogi smo predstavili več bolezenskih stanj, katera bi naj kurkumin izboljšal, ter študije oziroma raziskave, v katerih so te učinke kurkumina dokazali. Prav tako smo prej omenjene študije med seboj tudi primerjali. Delovanje kurkumina izhaja iz njegove sposobnosti vplivanja na veliko število signalnih molekul, kot so: pro-inflamatorni citokini, encimi, apoptozni proteini, adhezijske molekule, nuklearni faktorji in ostale. Nepravilno delovanje prej naštetih molekul in signalnih poti, v katerih te molekule sodelujejo, so mnoge študije povezale z razvojem raznih bolezenskih stanj. V nadaljevanju smo podrobneje pregledali spletno bazo PubMed. Z dodajanjem drugih ključnih besed smo raziskovalni vzorec postopoma omejevali. Osredotočali smo se na število študij, ki so bile izvedene in vivo ali pa in vitro, prav tako smo se osredotočali tudi na število študij, ki so se izvedle v kliničnem okolju. In this master thesis the plant Turmeric and its main constituent, curcumin has been thoroughly described. The plant Turmeric (Curcuma longa) is native to the Indian subcontinent and Southeast Asia and has a long history of use in the Ayurvedic medicine. Numerous studies have shown the positive effects of curcumin on different pathological conditions, such as cancer, ulcerative colitis, rheumatoid arthritis, pancreatitis, osteoarthritis and many other. What hinders the medicinal use of curcumin the most is its low bioavailability, since extremely low levels have been detected in blood plasma even after administering very high doses. In the thesis many different pathological conditions will be described, on which curcumin is supposed to have beneficial effects. We focused on various studies, who claim to have proved these beneficial effects. These aforementioned studies have also be compared with one another. Curcumin is capable of having an effect on many signalling molecules, such as pro-inflammatory cytokines, enzymes, apoptotic proteins, prostaglandins, cell adhesion molecules, NF–κB, COX-2, STAT3 and others. Irregularities in aforementioned molecules and signalling pathways have been linked to countless pathological conditions by numerous studies. In the following chapters we took a closer look at the online database PubMed. We were periodically narrowing our search by adding additional keywords, thus focusing ourselves on the number of studies, that had been carried out either in vivo or in vitro. We also focused on the number of studies, carried out in a clinical environment. kurkuma ajurvedska medicina signalne poti klinične študije nutracevtiki. turmeric ayurvedic medicine signalling pathways clinical studies nutraceuticals. true false false [T. Brumec] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2020-02-20 11:21:25 2020-06-11 12:11:36 2022-08-09 11:50:33 2020-06-12 03:13:26 2020 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 633.826:615.03(043.2) 19024899 URN:SI:UM:DK:VEHD97MI MAG_Brumec_Timotej_2020.pdf MAG_Brumec_Timotej_2020.pdf 1 C4A2A9DAD222A94831F0136F612C100C 6e2e2a26e0acd5de5b1f5f25a5b397a84fe8002297bfac2e120b1ee228d83d01 3a7833dc-7c11-11eb-bb7a-00155d0001ca 20.500.12556/dkum/1e99243d-533f-4a52-ad4f-fa435194f14d https://dk.um.si/Dokument.php?lang=slv&id=140742 Fakulteta za zdravstvene vede 0 0 0