20.500.12556/DKUM-79137 Cold agglutinins and cryoglobulins associate with clinical and laboratory parameters of cold urticaria Mast cell-activating signals in cold urticaria are not yet well defined and are likely to be heterogeneous. Cold agglutinins and cryoglobulins have been described as factors possibly associated with cold urticaria, but their relevance has not been explained. We performed a single-center prospective cohort study of 35 cold urticaria patients. Cold agglutinin and cryoglobulin test results, demographics, detailed history data, cold stimulation test results, complete blood count values, C-reactive protein, total immunoglobulin E levels, and basal serum tryptase levels were analyzed. Forty six percent (n = 16) of 35 tested patients had a positive cold agglutinin test and 27% (n = 9) of 33 tested patients had a positive cryoglobulin test. Cold agglutinin positive patients, when compared to cold agglutinin negative ones, were mainly female (P = 0.030). No gender-association was found for cryoglobulins. A positive cold agglutinin test, but not a positive cryoglobulin test, was associated with a higher rate of reactions triggered by cold ambient air (P = 0.009) or immersion in cold water (P = 0.041), and aggravated by increased summer humidity (P = 0.007). Additionally, patients with a positive cold agglutinin test had a higher frequency of angioedema triggered by ingestion of cold foods or drinks (P = 0.043), and lower disease control based on Urticaria Control Test (P = 0.023). Cold agglutinin levels correlated with erythrocyte counts (r = -0.372, P = 0.028) and monocyte counts (r = -0.425, P = 0.011). Cryoglobulin concentrations correlated with basal serum tryptase levels (r = 0.733, P = 0.025) and cold urticaria duration (r = 0.683, P = 0.042). Results of our study suggest that cold agglutinins and cryoglobulins, in a subpopulation of cold urticaria patients, are linked to the course and possibly the pathogenesis of their disease. cold-induced urticaria cold urticaria cryoglobulins cold agglutinin degranulation clinical parameters laboratory parameters mast cells cold triggers urtikarija zaradi mraza koprivnica krioglobulini hladni aglutinini degranulacija klinični parametri laboratorijski parametri mastociti hladni sprožilci true false true Frontiers Media SA Angleški jezik Slovenski jezik Znanstveno delo 2021-05-12 04:07:14 2024-08-07 11:47:14 2024-08-08 03:21:58 0000-00-00 00:00:00 2021 0 0 Str. 1-9 Št. članka 665491 Letn. 12 29 Apr. 2021 0000-00-00 Zaloznikova Objavljeno NiDoloceno 2021-02-08 2021-04-19 2021-04-29 616-097 30774233 61629187 10.3389/fimmu.2021.665491 1664-3224 Bizjak-2021-Cold_Agglutinins_and_Cryoglobulins.pdf Bizjak-2021-Cold_Agglutinins_and_Cryoglobulins.pdf 1 395F83287FD9FB13ACBDF498F363F414 6f545d9b996bceb42215c961333dc538ee65f0beb6cbf875a753fd630bd9d2e7 22f52d65-54a1-11ef-b534-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=182091 https://doi.org/10.3389/fimmu.2021.665491 0 c876a113-b2c6-11eb-bdb8-00155d581298 https://dk.um.si/Dokument.php?lang=slv&id=150179 Medicinska fakulteta 0 0 0