20.500.12556/DKUM-79693 Okoljsko prijazna in napredna funkcionalizacija silikona za razvoj novih medicinskih pripomočkov magistrsko delo Environmentally friendly and advanced functionalization of silicone for the development of new medical devices Prekomerna uporaba antibiotikov za zdravljenje infekcij vodi v naraščanje števila odpornih bakterij, kar predstavlja grožnjo javnemu zdravju. Strategije zmanjševanja uporabe temeljijo tudi na preprečevanju nastanka bakterijskega biofilma na površinah medicinskih pripomočkov. Predstavljamo metodo funkcionalizacije silikona z oplaščenjem z naravnimi bioaktivnimi substancami. Na silikon smo kot vezni polimer adsorbirali biopolimer polidopamin, na katerega smo kovalentno vezali karbokismetil hitozan s tiolnimi funkcionalnimi skupinami, ki izkazuje protimikrobne in biofilm-inhibitorne lastnosti. Rezultati karakterizacije so pokazali uspešno kovalentno vezavo karboksimetil hitozana preko tiolnih skupin na polidopamin, kar je pripomoglo k zmanjšanju tvorbe biofilma na površini v primerjavi s fizikalno vezanim karboksimetil hitozanom in neobdelanim silikonom. Excessive use of antibiotics to treat infections leads to an increase in the number of resistant bacteria, which poses a threat to public health. Strategies to reduce the use of antibiotics are also based on preventing the formation of bacterial biofilm on the surfaces of medical devices. In this work, we present a method of functionalizing silicone by coating it with natural bioactive substances. The biopolymer polydopamine was adsorbed on the silicon as a binding polymer, to which carboxymethyl chitosan was covalently bound with thiol functional groups exhibiting antimicrobial and biofilm-inhibitory properties. The characterization results showed successful covalent binding of carboxymethyl chitosan via thiol groups to polydopamine, which helped to reduce surface biofilm formation compared to physically bound carboxymethyl chitosan and untreated silicone. biopolimeri biofunkcionalizacija protimikrobnost polidopamin karboksimetil hitozan biopolymers biofunctionalization antimicrobial polydopamine carboxymethyl chitosan true true false [K. Kuzmič] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2021-08-11 20:20:18 2021-09-20 11:17:15 2022-08-09 21:55:04 0000-00-00 00:00:00 2021 0 Maribor 0 Maribor VIII, 71 str. 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577.11:615.8-7(043.2) 82421251 MAG_Kuzmic_Katja_2021.pdf MAG_Kuzmic_Katja_2021.pdf 1 42495C479840DD1E60166AB7F9A63E63 d3bad3579f2fb719d056012d44e4f835ab316e3c8c4e2bb81e114d5fa487b6bf df0e31f3-121c-11ec-99da-00155d581298 20.500.12556/dkum/562984da-ac84-4356-be31-d0b675d87f39 https://dk.um.si/Dokument.php?lang=slv&id=153537 Fakulteta za strojništvo 0 0 0