20.500.12556/DKUM-80440 Humani biomonitoring izpostavljenosti težkim kovinam in njihov potencialni učinek na zdravje prebivalcev Slovenije in Evropske unije med leti 2011 in 2014 Human biomonitoring of heavy metal exposure and its potential effect on the health of the Slovene population in the eEuropean union between 2011 and 2014 Humani biomonitoring je znanstveno razvit pristop za ocenjevanje izpostavljenosti ljudi kemikalijam, ki temelji na merjenju in spremljanju sprememb v tkivih, tekočinah, celicah oziroma biokemičnih procesih. V magistrskem delu smo za obdobje med leti 2011 in 2014 s pomočjo obstoječe domače in tuje literature ter dosedanjih raziskav na področju humanega biomonitoringa preučili izpostavljenost prebivalcev Slovenije in Evropske unije težkim kovinam in njihovemu potencialnemu vplivu na zdravje. Vsako izmed težkih kovin (kadmij, svinec, živo srebro, arzen) smo med seboj primerjali po posameznih biomarkerjih (kri, urin, humano mleko, lasje). Osredotočili smo se na referenčne vrednosti pri odraslih preiskovancih obeh spolov s povprečno starostjo med 18 in 49 leti. V raziskavah so bili najpogosteje uporabljeni biomarkerji kri, urin in humano mleko. V slovenski raziskavi je za višje ostanke težkih kovin v krvi in urinu v povprečju dovzetnejši moški spol, medtem ko je ženski spol dovzetnejši glede ostankov živega srebra v laseh. V preostalih študijah Evropske unije so moški v povprečju dosegli višje ostanke težkih kovin v krvi, ženski spol pa je višje ostanke težkih kovin dosegel v urinu. Predlagane referenčne vrednosti ostankov posameznih težkih kovin glede na preučevane biomarkerje so bile najpogosteje presežene v krvi, urinu in manj pogosteje v humanem mleku in laseh. Izpostavljenost splošnega prebivalstva težkim kovinam kadmija, svinca, živega srebra in arzena je nizka. Obremenjenost z merjenimi težkimi kovinami v splošnem ne predstavlja tveganja za preiskovano populacijo. Human biomonitoring is a scientifically developed approach for assessing human exposure to chemicals based on the measurement and monitoring of changes in tissues, fluids, cells or biochemical processes. For the period from 2011 to 2014, we examined the exposure of Slovene people and people residing in the European Union to heavy metals and their potential health impact, using existing domestic and foreign literature and previous research in the field of human biomonitoring. Each of the heavy metals (cadmium, lead, mercury, arsenic) was compared on each biomarker (blood, urine, human milk, hair). We focused on benchmarks in adult subjects of both sexes with an average age between 18 and 49 years. In the studies, the most commonly used biomarkers were blood, urine and human milk. In the study involving Slovenes, males were on average more susceptible to higher residues of heavy metals in blood and urine, while females were more susceptible to mercury residues in the hair. In other European Union countries, men achieved on average higher residues of heavy metals in the blood, while females reached higher residues of heavy metals in their urine. The proposed residue limits for individual heavy metals in relation to the biomarkers studied were most frequently exceeded in the blood and urine, and less frequently in human milk and hair. Exposure of the studied general population to heavy metals such as cadmium, lead, mercury and arsenic was low. The heavy metal load did not generally pose a risk to the population under investigation. humani biomonitoring biološki označevalec težke kovine biokemijske analize referenčne vrednosti human biomonitoring biological marker heavy metals biochemical analyzes reference values true true false Slovenski jezik Angleški jezik Magistrsko delo/naloga 2021-09-13 15:33:05 2021-09-28 11:31:37 2022-08-09 22:56:06 0000-00-00 00:00:00 2021 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 78121731 MAG_Novak_Barbara_2021.pdf MAG_Novak_Barbara_2021.pdf 1 5659E49DA6CEA74801CD00C2440579EE 3aafc594d4d9767ad8e80191e51ff04c4adcfcad2242caf8e5e76313c1ba5a06 ee7c275d-196c-11ec-82a9-00155d581298 20.500.12556/dkum/fdbed738-d31a-4444-ba25-1203256cadf5 https://dk.um.si/Dokument.php?lang=slv&id=154161 Fakulteta za kmetijstvo in biosistemske vede 0 0 0