20.500.12556/DKUM-81278 Tehnologije pri uporabi odprtih virov ionizirajočega sevanja v kliničnem okolju Technologies in use of open radioactive sources in clinical setting Uvod: V naravnem okolju obstaja več vrst sevanj, ki se delijo na ne-ionizirajoča in ionizirajoča. Slednja se delijo na odprte (nezatesnjene) in zaprte (zatesnjene) vire. Odprte vire uporablja nuklearna medicina, ki pri delu z njimi uporablja različne tehnologije. Metode: V teoretičnem delu smo uporabili deskriptivno metodo. V empiričnem delu smo pregledali dokumentacijo institucije in izvajali meritve. Opravili smo enocentrično raziskavo v kliničnem okolju. Vključili smo 5 odprtih in 3 zaprte vire ionizirajočega sevanja. Z medicinsko tehnologijo, ki se uporablja v kliničnem okolju, smo izvajali meritve aktivnosti ob dostavi. Hitrosti doze smo merili na razdalji enega metra od vira in tik ob viru v njegovi zaščiti. Vzorec je zajemal 10 meritev posameznih odprtih in zaprtih virov. Izvedli smo simulacijo diagnostične aplikacije radiofarmaka 18F-FDG s pomočjo sistema za infundiranje MEDRAD® Intego PET Infusion System (INT SYS 200). Rezultati: Ugotovili smo, da se odprti viri ionizirajočega sevanja v kliničnem okolju večinoma uporabljajo v diagnostične, majhen del pa v terapevtske namene. Najbolj uporabljen radionuklid je še vedno 99mTc. Na njem temelji največ radiofarmakov. Sledi mu radiofarmak 18F-FDG. Najvišjo aktivnost ob dostavi je imel generator 99Mo/99mTc (93,43 ± 32,57 GBq), najmanjšo pa DaTSCAN (123I) (293,78 ± 15,17 MBq). Najvišjo povprečno hitrost doze ob zaščiti je imel 18F-FDG (25527,37 ± 5593,52 μSv/h), najmanjšo pa RaJ (131I) (180,20 ± 8,41 μSv/h). Zaključek: Odprti viri ionizirajočega sevanja se najpogosteje pripravljajo in aplicirajo ročno, majhen del pa s pomočjo sistema za infundiranje. Simulacijo priprave in ročne aplikacije je možno izvesti izven kliničnega okolja, medtem ko je simulacija s sistemom za infundiranje omejena na sam aparat. Introduction: There are several types of radiation in the natural environment, which are divided into non-ionizing and ionizing. The latter are divided into unsealed and sealed sources. Unsealed sources are used in nuclear medicine, that uses different various technologies for working with them. Methods: In theoretical part we used a descriptive method. In the empirical part we reviewed the documentation of the institution and carried out measurements. We conducted a single-centric survey in clinical setting. We have included 5 unsealed and 3 sealed sources of ionizing radiation. With the medical technology used in clinical setting, we performed measurements of the activity at the delivery. The dose rate was measured at the distance of one meter from the source and right nexr the source in its shield. The sample covered 10 measurements of individual unsealed and sealed sources. We performed a simulation of the diagnostic administration of the 18F-FDG radiopharmaceutical using the MEDRAD® Intego PET Infusion System (INT SYS 200). Discussion: We found that unsealed sources of ionizing radiation in the clinical environment are mostly used in diagnostic, and small part in therapeutic purposes. The mostly used radionuclide is still 99mTc. The most radiopharmaceuticals are based on it. It is followed by a radiopharmaceutical 18F-FDG. The highest activity at the delivery had a 99Mo/99mTc generator (93,43 ± 32,57 GBq) and the lowest DaTSCAN (123I) (293,78 ± 15,17 MBq). The highest average dose rate at shield had 18F-FDG (25527,37 ± 5593,52 μSv/h), and the lowest had RAI (131I) (180,20 ± 8,41 μSv/h). Conclusion: Unsealed sources of ionizing radiation are most often prepared and administered manually, and a small part with the help of the infusion system. The simulation of the preparation and manual administration can be carried out the clinical environment, while the simulation with infusion system is limited to the appliance itself. nuklearna medicina radiofarmak sistem za infundiranje gama kamera radionuklidna terapija nuclear medicine radiopharmaceutical infusion system gamma camera radionuclide therapy true false false [G. Pintarič] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2022-02-11 10:57:45 2022-06-17 16:22:49 2023-02-14 03:06:25 0000-00-00 00:00:00 2022 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 613.648.4:61:539.1(043.2) 112034819 MAG_Pintaric_Gregor_2022.pdf MAG_Pintaric_Gregor_2022.pdf 1 EA9180E06328FA86640E8358B74EFBEB 727a44fd31c5bf36f324f461a30ee5acf35657e1e06489ae1806b73c05f0a2ae d50b3ac8-abab-11ed-97bc-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=165683 Fakulteta za zdravstvene vede 0 0 0