20.500.12556/DKUM-81447 Antigenotoksični potencial rožmarinskih ekstraktov magistrsko delo Antigenotoxic potential of rosemary extracts V magistrski nalogi smo preučevali delovanje rožmarinskih ekstraktov (1 % in 2 %) na človeške celice in poskušali pokazati, da rožmarin deluje antigenotoksično in antioksidativno. V raziskavi smo uporabili celice človeškega hepatocelularnega hepatoma (HepG2). S pomočjo testa MTT smo preučevali citotoksičnost samih ekstraktov, s testom komet pa morebitne poškodbe DNK po izpostavitvi celic proučevanim spojinam v kombinaciji s tert-butil hidroksidom (t-BHP) in aflatoksinom B1 (AFB1). In the Master thesis we studied the effect of rosemary extracts (1 % and 2 %) on human cells and tried to show that rosemary exhibits antigenotoxic and antioxidant effects. Human hepatocellular hepatoma cells (HepG2) were used in the studies. Using the MTT test, we studied the cytotoxicity of the extracts themselves, with the comet test we tested a possible DNA cell damage after treatment with the studied compounds in combination with tert-butyl hydroxide (t-BHP) and aflatoxin B1 (AFB1). rožmarinski ekstrakt rožmarinska kislina AFB1 t-BHP antioksidant antigenotoksičen test MTT test komet HepG2 rosemary extract rosemary acid AFB1 t-BHP antioxidant antigenotoxic MTT test comet test HepG2 true true false [K. Lečnik] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2022-03-27 21:51:04 2022-05-03 13:12:41 2022-08-10 00:29:11 0000-00-00 00:00:00 2022 0 Maribor 0 Maribor 1 spletni vir (1 datoteka PDF (VII, 34 f.)) 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577(043.2) 106736131 MAG_Lecnik_Katja_2022.pdf MAG_Lecnik_Katja_2022.pdf 1 852F3CB9260BF255A0D70B3E4CFBE40C 102d4fa012a1f60feff18493cbe2deca99aaaaa2ecfbd8c1dcbb87862801c3de fc1bfa9e-c7de-11ec-a00a-00155d000105 20.500.12556/dkum/b69bb4a9-7809-47fd-801f-4045c06f4a21 https://dk.um.si/Dokument.php?lang=slv&id=157561 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0