20.500.12556/DKUM-81975 Pospešena ateroskleroza pri bolnicah z revmatoidnim artritisom in pomen metaloproteaz ter novejših biokemičnih kazalcev Accelerated Atherosclerosis in Rheumatoid Arthritis Patients and the Importance of Metalloproteinases and New Biochemical Markers Bolniki z revmatoidnim artritisom (RA) imajo krajšo pričakovano življenjsko dobo, glavni vzrok smrti predstavljajo srčno-žilna obolenja. Povečanega tveganja ni mogoče pojasniti zgolj s klasičnimi dejavniki tveganja (debelost, povišan krvni tlak, hiperlipidemija, kajenje). Vedno več je dokazov, da bi lahko kronično vnetje povečevalo tveganje za srčno žilna obolenja. V naši prospektivni raziskavi smo 15 let opazovali 70 bolnic z RA in 40 zdravih kontrol, brez klasičnih dejavnikov tveganja, ob vključitvi so bile vse premenopavzalne. Spremljali smo klasične dejavnike tveganja, vnetne pokazatelje (sedimentacijo, C reaktivni protein), citokine (interlevkin-6 (IL-6), tumorje nekrotizirajoči faktor alfa (TNF alfa)) in adhezijske molekule (ICAM in VCAM). Prisotnost aterosklerotičnega procesa smo ocenjevali z ultrazvočno preiskavo karotidnih arterij. Preiskovanke z RA so imele enako debelino intimo medije kot zdrave kontrole, potrdili pa smo statistično višje število plakov pri bolnicah z RA, kot pri zdravih kontrolah. Med skupinama ni bilo razlik v primerjavi klasičnih dejavnikov tveganja, potrdili smo statistično pomembne razlike v neklasičnih dejavnikov tveganja. Rezultati podpirajo teorijo vnetja kot dejavnika tveganja za pospešeno aterosklerozo pri bolnicah z RA. Patients with rheumatoid arthritis (RA) have a lower life expectancy, with cardiovascular disease being the leading cause of death. The increased risk cannot be explained only by traditional risk factors (obesity, high blood pressure, hyperlipidemia, smoking). There is growing evidence that chronic inflammation may increase the risk of cardiovascular disease. In our prospective research, we followed 15 RA patients and 40 healthy controls for 15 years; at the time of enrollment all participants were premenopausal. Traditional risk factors, inflammatory markers (sedimentation (ESR), C-reactive protein), cytokines (interleukin 6 (IL-6)), tumor necrosis factor alpha (TNF-alpha) and adhesion molecules (ICAM and VCAM) were monitored. The results of a carotid artery ultrasound scan were used to detect the presence of atherosclerotic process. Subjects with RA had the same intima-media thickness as healthy controls; however, we found that RA patients had a statistically larger number of plaques compared to healthy controls. Although there were no differences between the groups when it came to traditional risk factors, we did find statistically significant variations in non-traditional risk factors. The findings support the theory that inflammation is a risk factor for accelerated atherosclerosis in RA patients. revmatoidni artritis ateroskleroza metaloproteainaze rheumatoid arthritis atherosclerosis metalloproteinases true true false Slovenski jezik Angleški jezik Doktorsko delo/naloga 2022-06-23 18:16:20 2023-10-24 08:05:57 2023-10-25 03:11:24 0000-00-00 00:00:00 2023 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 169566467 DOK_Koren_Krajnc_Metka_2023.pdf DOK_Koren_Krajnc_Metka_2023.pdf 1 72233315B38C64C3BA8194FBF7824617 9b0905f845dd7b00b296b978713fc283e94aad9b0593745fe21b2d1e4e585d92 17de9458-6f83-11ee-a7b6-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=173664 Medicinska fakulteta 0 0 0