20.500.12556/DKUM-82314 Analiza povezav med arterijsko togostjo, ekspresijskim profilom mikroRNK iz periferne krvi in stopnjo aterosklerotične prizadetosti koronarnih arterij pri bolnikih z normalnim ali zmanjšanim ledvičnim delovanjem The association between arterial stiffness parameters, microRNA expression profile from peripheral blood and the extent of coronary artery disease in patients with normal or reduced kidney function Ateroskleroza je kronična vnetna bolezen arterij, ki vodi v zoženje svetline žil ter v ishemično okvaro tkiv in organov v povirju prizadetih arterij. Med srčnožilne bolezni uvrščamo ishemično bolezen srca, periferno arterijsko bolezen, bolezni možganskih žil ter anevrizme prsne in trebušne aorte. Predstavljajo enega izmed najpogostejših vzrokov umrljivosti v razvitem svetu in so neposredna posledica napredovale ateroskleroze. Kronična ledvična bolezen je pomemben dejavnik tveganja za srčnožilne bolezni. Arterijska togost označuje zmanjšano podajnost arterij in je povezana s strukturnimi in funkcionalnimi spremembami v žilni steni in pretoku krvi. MikroRNK so ključni epigenetski regulatorji številnih procesov v telesu in imajo velik potencial pri prepoznavanju in zdravljenju srčnožilnih bolezni. V naši študiji smo analizirali povezave med koronarno arterijsko boleznijo, periferno arterijsko boleznijo in arterijsko togostjo pri bolnikih z in brez kronične ledvične bolezni. Prav tako smo analizirali ekspresijski profil mikroRNK molekul pri bolnikih z najvišjimi in najnižjimi vrednostmi hitrosti karotidno-femoralnega pulznega vala. Rezultati naše študije dokazujejo, da imajo bolniki s kronično ledvično boleznijo višjo arterijsko togost ter nižji gleženjski indeks. Pri bolnikih s kronično ledvično boleznijo je bilo nekoliko več trožilne koronarne arterijske bolezni, vendar razlika v primerjavi z bolniki brez kronične ledvične bolezni ni bila statistično pomembna. V ekspresiji mikroRNK razlik ni bilo. Atherosclerosis is a chronic inflammatory disease of the arteries that leads to narrowing of the lumen of blood vessels and ischemic damage to target tissues and organs. The spectrum of cardiovascular disease includes ischemic heart disease, peripheral artery disease, cerebrovascular disease, thoracic and abdominal aortic aneurysms. Cardiovascular disease is one of the most common causes of mortality in the devel-oped world and is a direct consequence of advanced atherosclerosis. Chronic kidney disease is an important risk factor for cardiovascular disease. Arterial stiffness indi-cates decreased arterial distensibility and is associated with structural and functional changes of vascular walls and blood flow. MicroRNAs are key epigenetic regulators of many processes in the body and have great potential in the recognition and treatment of cardiovascular disease. In our study, we analysed the associations between coronary artery disease, peripheral artery disease and arterial stiffness in patients with and without chronic kidney disease. Additionally, we performed an analysis of microRNA expression in patients with the highest and lowest carotid-femoral pulse wave velocities. We demonstrated that patients with chronic kidney disease have higher arterial stiffness and decreased ankle-brachial index. More patients with three vessel coronary artery disease had chronic kidney disease, although the difference was not statistically significant. There were no differences in microRNA expression profile between patients with 10 highest and 10 lowest values of carotid-femoral pulse wave velocity. ateroskleroza arterijska togost kronična ledvična bolezen srčnožilna bolezen mikro RNK atherosclerosis arterial stiffness chronic kidney disease cardiovascular disease micro RNA true true false Slovenski jezik Angleški jezik Doktorsko delo/naloga 2022-08-13 13:21:46 2023-02-16 13:26:15 2023-02-17 03:06:41 0000-00-00 00:00:00 2022 0 Maribor 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 141963779 DOK_Piko_Nejc_2023.pdf DOK_Piko_Nejc_2023.pdf 1 B73C4FBD3AFA03B05BEEC0E32139C6A3 9bd28c647ecf971b01c7e076ddc134ff5fa08d0febaa3432aca8c5d39d5452fa 1f6add1c-9f46-11ed-bd5e-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=165481 Medicinska fakulteta 0 0 0