20.500.12556/DKUM-82773 Poliakrilatne membrane za nadzorovano sproščanje diplomsko delo univerzitetnega študijskega programa I. stopnje Polyacrylate membranes for controlled release V okviru diplomskega dela smo si zadali dva glavna cilja, sintetizirati visoko porozne polimerne membrane in le-te uporabiti za nadzorovano sproščanje zdravilne učinkovine. Porozne polimerne membrane smo sintetizirali s polimerizacijo emulzij z visokim deležem notranje faze, pri čemer je vodna faza vsebovala monomer (2-hidroksietil metakrilat), zamreževalo (metilenbisakrilamid), deionizirano vodo in surfaktant (Pluronic F86), za organsko fazo smo uporabili cikloheksan. V primeru termično iniciirane polimerizacije smo iniciator (amonijev persulfat) dodali v vodno fazo in v primeru fotopolimerizacije (Irgacure 819) v organsko fazo. Nastale polimerne membrane smo okarakterizirali s FTIR-spektroskopijo in elementnim analizatorjem za spremljanje uspešnosti vključevanja monomera in zamreževala v polimerno verigo, z vrstičnim elektronskim mikroskopom za preučevanje morfologije membran in s porozimetrom z absorpcijo/desorpcijo plina dušika po Brunauer-Emmet-Tellerjevi metodi za določanje specifične površine. Uspešnejša je bila sinteza membran s fotopolimerizacijo, s katerimi nam je uspelo doseči v membranah odprto celično strukturo, ki je membrane, polimerizirane s termično polimerizacijo, niso imele. Porozne membrane smo nadalje uporabili za preučevanje nadzorovanega sproščanja paracetamola. Najprej smo membrane nekaj ur namakali v vodni raztopini paracetamola, nato smo jih po spiranju s curkom deionizirane vode potopili v deionizirano vodo in z UV Visom spremljali sproščanje paracetamola v odvisnosti od časa. Rezultati so pokazali, da so membrane uspešno absorbirale paracetamol ter ga različno hitro in različno veliko sprostile.  In this thesis, we set ourselves two main goals, to synthesize highly porous polymer membranes and to use them for the controlled release of the active substance. Porous polymer membranes were synthesized by polymerization of emulsions with a high proportion of the internal phase, where the water phase contained a monomer (2-hydroxyethyl methacrylate), a cross-linker (methylenebisacrylamide), deionized water and a surfactant (Pluronic F86), while cyclohexane was used for the organic phase. In the case of thermally initiated polymerization, the initiator (ammonium persulfate) was added to the water phase, and in the case of photopolymerization (Irgacure 819) the initiator was added to the organic phase. The resulting polymer membranes were characterized with FTIR spectroscopy and an elemental analyzer to monitor the successful incorporation of monomer and crosslinker into the polymer chain, with a scanning electron microscope to study the morphology of the membranes and with a porosimeter with nitrogen gas absorption/desorption according to the Brunauer-Emmet-Teller method to determine the specific surface area. More successful was the synthesis of membranes by photopolymerization, which we managed to achieve with an open cellular structure in the membranes, which membranes polymerized by thermal polymerization did not have. The porous membranes were further used to study the controlled release of paracetamol. First, the membranes were soaked in a water solution of paracetamol for several hours, then they were immersed in deionized water after being rinsed with it. The release of paracetamol was monitored with UV Vis as a function of time. The results showed that the membranes successfully absorbed paracetamol and released it at different rates and in different amounts. porozni polimeri fotopolimerizacija HIP-emulzija sproščanje zdravilnih učinkovin paracetamol Porous polymers photopolymerization HIP emulsion transport of medical substances true true false [L. Berložnik] Slovenski jezik Angleški jezik Diplomsko delo/naloga 2022-09-01 13:37:02 2022-09-16 12:30:49 2022-11-23 03:06:23 0000-00-00 00:00:00 2022 0 Maribor 0 Maribor 1 spletni vir (1 datoteka PDF (X, 39 f.)) 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 539.12.52:678.744.32:615.015.15(043.2) 130440195 UN_Berloznik_Lara_2022.pdf UN_Berloznik_Lara_2022.pdf 1 9E3F68B9B7717DBA8C4043B0324173FA a2438f05e11afe60acb352cf9913b4ca43d1c59ec9db394c1c8b741cdd2d2430 5da6f151-34ed-11ed-8b31-00155d000105 https://dk.um.si/Dokument.php?lang=slv&id=162767 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0